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From Neanderthal to Nanobiotech: From Plant Potions to Pharming with Plant Factories

  • Protocol
Recombinant Proteins From Plants

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 483))

Summary

Plants were the main source for human drugs until the beginning of the nineteenth century when plantderived pharmaceuticals were partly supplanted by drugs produced by the industrial methods of chemical synthesis. During the last decades of the twentieth century, genetic engineering has offered an alternative to chemical synthesis, using bacteria, yeasts and animal cells as factories for the production of therapeutic proteins. After a temporary decrease in interest, plants are rapidly moving back into human pharmacopoeia, with the recent development of plant-based recombinant protein production systems offering a safe and extremely cost-effective alternative to microbial and mammalian cell cultures. In this short review, we will illustrate that current improvements in plant expression systems are making them suitable as alternative factories for the production of either simple or highly complex therapeutic proteins.

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Acknowledgments

Work on glycobiology at the University of Rouen was supported by the Centre National de la Recherche Scientifique (CNRS) and by the “Ministère de la Recherche”. We thank present and former colleagues who contributed to the work described in this review and for their critical reading of the manuscript.

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Authors and Affiliations

  1. Faculté des Sciences, Université de Rouen, Mont Saint, Aignan, France

    Christophe Sourrouille

  2. MolecularFarming.com, Ballyhaskey, Newtowncunningham, Lifford, Donegal Ireland

    Brian Marshall

  3. LI LIU, Department of Biological Chemistry, John Innes Centre, Colney Lane, Norwich, UK

    David Liénard

  4. CNRS, Université de Rouen, Mont Saint, Aignan, France

    Loïc Faye

Authors
  1. Christophe Sourrouille
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  2. Brian Marshall
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  3. David Liénard
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  4. Loïc Faye
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Editors and Affiliations

  1. CNRS, Université de Rouen, Mont Saint Aignan, France

    Loïc Faye  & Véronique Gomord  & 

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Sourrouille, C., Marshall, B., Liénard, D., Faye, L. (2009). From Neanderthal to Nanobiotech: From Plant Potions to Pharming with Plant Factories. In: Faye, L., Gomord, V. (eds) Recombinant Proteins From Plants. Methods in Molecular Biology™, vol 483. Humana Press. https://doi.org/10.1007/978-1-59745-407-0_1

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  • DOI: https://doi.org/10.1007/978-1-59745-407-0_1

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-978-9

  • Online ISBN: 978-1-59745-407-0

  • eBook Packages: Springer Protocols

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