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Arthritis Research pp 225–242Cite as

Arthritis Induced with Minor Cartilage Proteins

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Part of the book series: Methods in Molecular Medicine ((MIMM,volume 136))

Abstract

Type XI collagen (CXI) and cartilage oligomeric matrix protein (COMP) are minor components in cartilage, shown to be arthritogenic. CXI is a heterotrimeric triple helical fibrillar collagen and intermingled in the collagen fibers with type II (CII). COMP is the major noncollagenous protein of cartilage and is a homopentamer, interacting with the collagen fibers with each of its subunits. Similar to CII, homologous rat CXI also induces a chronic arthritis in rats but with a different major histocompatibility complex (MHC) genetic control and pathogenesis. CXI induced arthritis (CXIIA) is characterized by a more pronounced chronic relapsing disease course. The MHC allele of importance is the RT1f haplotype and, surprisingly, some of the CII associated MHC alleles like RT1a are less permissive. Immunization with COMP induces a severe but self-limited arthritis in strains with a genetic background resistant to most other forms of arthritis or even autoimmune models, the E3 rat. The MHC association also differs between the different models (CIA, CXI, and COMPIA). An autoimmune response to COMP is triggered despite the circulation of COMP fragments in both physiologic and arthritic states. The induction of arthritis in rats with CXI or COMP provides an arthritis models with a distinct pathogenesis as compared with other induced arthritis models.

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Authors and Affiliations

  1. Medical Inflammation Research, Lund University, Lund, Sweden

    Stefan Carlsen, Shemin Lu & Rikard Holmdahl

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  1. Stefan Carlsen
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  2. Shemin Lu
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  3. Rikard Holmdahl
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  1. The Kennedy Institute of Rheumatology, Imperial College London, London, UK

    Andrew P. Cope

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© 2007 Humana Press Inc., Totowa, NJ

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Carlsen, S., Lu, S., Holmdahl, R. (2007). Arthritis Induced with Minor Cartilage Proteins. In: Cope, A.P. (eds) Arthritis Research. Methods in Molecular Medicine, vol 136. Humana Press. https://doi.org/10.1007/978-1-59745-402-5_17

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  • DOI: https://doi.org/10.1007/978-1-59745-402-5_17

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-918-5

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