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Frontiers of Immunological Tolerance

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Book cover Immunological Tolerance

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 380))

Abstract

Herein, we succinctly review mechanisms underlying self-tolerance and the roles of dendritic leukocytes (DCs) in T-cell tolerance to self and foreign antigens. We also consider the properties of naturally arising and other populations of regulatory T cells (Treg), together with growing evidence that interplay between DCs and Treg cells can sustain antigen-specific tolerance. B-cell tolerance and the role of hematopoietic cell chimerism in the induction and maintenance of tolerance are also discussed, as is the impact of cosignaling pathway manipulation on tolerance induction. This overview also surveys prospects for technological advances in the monitoring and prediction of tolerance and the application of genomic and proteomic analysis. In addition, we consider potential novel therapeutic targets for promotion of tolerance induction.

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Authors and Affiliations

  1. Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA

    Giorgio Raimondi, Hēeth R. Turnquist & Angus W. Thomson

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  1. Giorgio Raimondi
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  2. Hēeth R. Turnquist
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  3. Angus W. Thomson
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Editors and Affiliations

  1. Sir William Dunn School of Pathology, University of Oxford, Oxford, UK

    Paul J. Fairchild

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© 2007 Humana Press Inc., Totowa, NJ

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Raimondi, G., Turnquist, H.R., Thomson, A.W. (2007). Frontiers of Immunological Tolerance. In: Fairchild, P.J. (eds) Immunological Tolerance. Methods in Molecular Biology™, vol 380. Humana Press. https://doi.org/10.1007/978-1-59745-395-0_1

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  • DOI: https://doi.org/10.1007/978-1-59745-395-0_1

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-652-8

  • Online ISBN: 978-1-59745-395-0

  • eBook Packages: Springer Protocols

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