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A History of Association Mapping

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Linkage Disequilibrium and Association Mapping

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 376))

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Abstract

The current exciting developments in association mapping are founded on theory, which has been developed since the beginning of the last century. I hereby review these developments in their historical context.

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References

  1. Robbins, R. B. (1918) Some applications of mathematics to breeding problems. III. Genetics 3, 375–389.

    CAS  PubMed  Google Scholar 

  2. Ford, E. B. (1940) Polymorphism and taxonomy, in The New Systematics (Huxley, J., ed.), Clarendon Press, Oxford, UK, pp. 493–513.

    Google Scholar 

  3. Wright, S. (1931) Evolution in mendelian populations. Genetics 16, 97–159.

    CAS  PubMed  Google Scholar 

  4. Kimura, M. and Ohta, T. (1973) Mutation and evolution at the molecular level. Genetics Supplement 73, 19–135.

    CAS  Google Scholar 

  5. Morton, N. E., Zhang, W., Taillon-Miller, P., Ennis, S., Kwok, P. Y., and Collins, A. (2001) The optimal measure of allelic association. Proc. Natl. Acad. Sci. USA 98, 5217–5221.

    Article  CAS  PubMed  Google Scholar 

  6. Sinascalco, M., Bernini, L., Latte, B., and Motulsky, A. G. (1961) Favism and thalassemia in Sardinia and their relationship to Malaria. Nature 190, 1179–1180.

    Article  Google Scholar 

  7. Adam, A. (1961) Linkage between G-6-P-D deficiency and colour-blindness. Proc. 2nd Inter. Cong. Hum. Genet. Rome, Italy, pp. 565–567, Excerpta Med. E53.

    Google Scholar 

  8. Porter, I. H., Schulze, J., and McKusick, V. A. (1962) Genetical linkage between the loci for glucose-6-phosphate dehydrogenase deficiency and colour-blindness in American Negroes. Ann. Hum. Genet. 26, 107–122.

    Article  CAS  PubMed  Google Scholar 

  9. Lewontin, R. (1988) On measures of gametic disequilibrium. Genetics 120, 849–852.

    CAS  PubMed  Google Scholar 

  10. Collins, A. and Morton, N. E. (1998) Mapping a disease locus by allelic association. Proc. Natl. Acad. Sci. USA 95, 1741–1745.

    Article  CAS  PubMed  Google Scholar 

  11. Bennett, J. H. (1965) Estimation of the frequencies of linked gene pairs in random mating populations. Amer. J. Hum. Genet. 17, 51–53.

    CAS  PubMed  Google Scholar 

  12. Hill, W. G. (1974) Estimation of linkage disequilibrium in randomly mating populations. Heredity 33, 229–239.

    Article  CAS  PubMed  Google Scholar 

  13. Hill, W. G. and Robertson, A. (1968) Linkage disequilibrium in finite populations. Theor. Appl. Genet. 38, 226–231.

    Article  Google Scholar 

  14. Sved, J. A. (1970) Linkage disequilibrium and homozygosity of chromosome segments in finite populations. Theor. Pop. Biol. 2, 125–141.

    Article  Google Scholar 

  15. Malecot, G. (1948) Les mathématiques de l’hérédité. Mason et Cie, Paris, France.

    Google Scholar 

  16. Chakravarti, A., Buetow, K. H., Antonarakis, S. E., Waber, P. G., Boehm, C. D., and Kazazian, H. H. (1984) Nonuniform recombination within the human beta-globin gene cluster. Am. J. Hum. Genet. 36, 1239–1259.

    CAS  PubMed  Google Scholar 

  17. Daly, M. J., Rioux, J. D., Schaffner, S. F., Hudson, T. J., and Lander, E. S. (2001) High-resolution haplotype structure in the human genome. Nat. Genet. 29, 229–232.

    Article  CAS  PubMed  Google Scholar 

  18. Kerem, B., Rommens, J. M., Buchanan, J. A., et al. (1989) Identification of the cystic fibrosis gene: genetic analysis. Science 245, 1073–1080.

    Article  CAS  PubMed  Google Scholar 

  19. Terwilliger, J. D. (1995) A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more marker loci. Am. J. Hum. Genet. 56, 777–787.

    CAS  PubMed  Google Scholar 

  20. Devlin, B. and Reisch, N. (20) A comparison of linkage disequilibrium measures for fine scale mapping. Genomics 29, 311–322.

    Google Scholar 

  21. Risch, N. and Merikangas, K. (1996) The future of genetic studies of complex human diseases. Science 273, 1516–1517.

    Article  CAS  PubMed  Google Scholar 

  22. McVean, G. A., Myers, S. R., Hunt, S., Deloukas, P., Bentley, D. R., and Donnelly, P. (2004) The fine scale structure of recombination rate variation in the human genome. Science 304, 581–584.

    Article  CAS  PubMed  Google Scholar 

  23. International Human Genome Sequencing Consortium (2004) Finishing the euchromatic sequence of the human genome. Nature 431, 931–945.

    Article  Google Scholar 

  24. International HapMap Consortium (2005) A haplotype map of the human genome. Nature 437, 1299–1320.

    Article  Google Scholar 

  25. Maniatis, N., Collins, A., Xu, C. F., et al. (2002) The first linkage disequilibrium (LD) maps: delineation of hot and cold blocks by diplotype analysis. Proc. Natl. Acad. Sci. USA 99, 2228–2233.

    Article  CAS  PubMed  Google Scholar 

  26. Zhang, W., Collins, A., Maniatis, N., Tapper, W. J., and Morton, N. E. (2002) Properties of linkage disequilibrium (LD) maps. Proc. Natl. Acad. Sci. USA 99, 17,004–17,007.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Genetic Epidemiology and Bioinformatics Group, Human Genetics Division, Southampton General Hospital, Southampton, UK

    Newton E. Morton

Authors
  1. Newton E. Morton
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Editor information

Editors and Affiliations

  1. Genetic Epidemiology and Bioinformatics Group, Human Genetics Division Southampton General Hospital, Southampton, UK

    Andrew R. Collins

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© 2007 Humana Press Inc.

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Morton, N.E. (2007). A History of Association Mapping. In: Collins, A.R. (eds) Linkage Disequilibrium and Association Mapping. Methods in Molecular Biology™, vol 376. Humana Press. https://doi.org/10.1007/978-1-59745-389-9_2

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  • DOI: https://doi.org/10.1007/978-1-59745-389-9_2

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-669-6

  • Online ISBN: 978-1-59745-389-9

  • eBook Packages: Springer Protocols

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