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Linkage Disequilibrium and Association Mapping

An Introduction

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Linkage Disequilibrium and Association Mapping

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 376))

Abstract

The basis for recent developments on the characterization of the linkage-disequilibrium structure of the genome and the application of association mapping to genes for common human diseases is described. Patterns of linkage disequilibrium are now understood, for a number of human populations, in unprecedented detail. This information not only provides a vital resource for the design and execution of powerful association-mapping studies, but opens new avenues of research into the genetic history of human populations and the effects of natural selection, mutation, and recombination on the genomic landscape.

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Author information

Authors and Affiliations

  1. Genetic Epidemiology and Bioinformatics Group, Human Genetics Division, Southampton General Hospital, Southampton, UK

    Andrew R. Collins

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  1. Andrew R. Collins
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Editor information

Editors and Affiliations

  1. Genetic Epidemiology and Bioinformatics Group, Human Genetics Division Southampton General Hospital, Southampton, UK

    Andrew R. Collins

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© 2007 Humana Press Inc.

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Collins, A.R. (2007). Linkage Disequilibrium and Association Mapping. In: Collins, A.R. (eds) Linkage Disequilibrium and Association Mapping. Methods in Molecular Biology™, vol 376. Humana Press. https://doi.org/10.1007/978-1-59745-389-9_1

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  • DOI: https://doi.org/10.1007/978-1-59745-389-9_1

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-669-6

  • Online ISBN: 978-1-59745-389-9

  • eBook Packages: Springer Protocols

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