Evaluation of Diagnostic Tests

  • John M. FardyEmail author
Part of the Methods in Molecular Biology™ book series (MIMB, volume 473)


As technology advances, diagnostic tests continue to improve, and each year, we are presented with new alternatives to the standard procedures. Given the plethora of diagnostic alternatives, diagnostic tests must be evaluated to determine their place in the diagnostic armamentarium. Criteria include sensitivity and specificity, positive and negative predictive values, likelihood ratios for positive and negative tests, and receiver operating characteristic curves. The prevalence of disease influences the diagnostic utility of tests, particularly when diseases are rare or very frequent.

Key words

Diagnostic tests sensitivity specificity positive predictive value negative predictive value likelihood ratio receiver operating characteristic curve 


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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Health Sciences CentreNewfoundlandCanada

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