Analysis of Randomized Controlled Clinical Trials

  • Robert N. FoleyEmail author
Part of the Methods in Molecular Biology™ book series (MIMB, volume 473)


When analyzing the results of a trial, the primary outcome variable must be kept in clear focus. In the analysis plan, consideration must be given to comparing the characteristics of the subjects, taking account of differences in these characteristics; intention-to-treat analysis; interim analyses and stopping rules; mortality comparisons; composite outcomes; research design including run-in periods, factorial, stratified, and crossover designs; number needed to treat; power issues; multivariate modeling; and hypothesis-generating analyses.

Key words

Randomized controlled trials analysis intention to treat research design stopping rules multivariate modeling 


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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.USRDSMinneapolisUSA

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