Abstract
Caloric restriction remains the only nongenetic intervention that has been consistently and reproducibly shown to extend both average and maximal lifespan in a wide variety of species. If shown to be applicable to human aging, it is unlikely that most people would be able to maintain the 30–40% reduction in food intake apparently required for this intervention. Therefore, an alternative approach is needed. We first proposed the concept of caloric restriction (CR) mimetics in 1998. Since its introduction, this research area has witnessed a significant expansion of interest in academic, government, and private sectors. CR mimetics target alteration of pathways of energy metabolism to potentially mimic the beneficial health-promoting and anti-aging effects of CR without the need to reduce food intake significantly. To date, a number of candidate CR mimetics including glycolytic inhibitors, antioxidants and specific gene-modulators have been investigated and appear to validate the potential of this approach.
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Weindruch, R. and Walford, R. (1988) The Retardation of Aging and Disease by Dietary Restriction. Thomas, Springfield, IL.
Roth, G. S., Ingram, D. K., and Lane, M. A. (1999) Calorie restriction in primates: will it work and how will we know? J. Am. Geriatr. Soc. 47, 896–903.
Vallejo, E. A. (1957) La Dieta de Hombre a Dias Alterno in a la Alimentacion de Los Viejos. Rev. Clin. Exp. 63, 25–49.
Kagawa, Y. (1978) Impact of Westernization on the nutrients of Japanese: changes in physique, cancer, longevity, and centenarians. Prev. Med. 7, 205–227.
Lane, M. A., Mattision, J., Ingram, D. K., and Roth, G. K. (2002) Caloric restriction and aging in primates: relevance to humans and possible CR mimetics. Micros. Res. Tech. 59, 335–338.
Black, A., Tilmont, E. M., Handy, A. M., Ingram, D. K., Roth, G. S., and Lane, M. A. (2000) Calorie restriction reduces the incidence of proliferative disease: preliminary data from the NIA CR in nonhuman primate study (abstract). Gerontologist 40, 5.
Roth, G. S., Lane, M. A., Ingram, D. K., et al. (2002) Biomarkers of caloric restriction may predict longevity in humans. Science 297, 881.
Heilbronn, L. (2004) Paper presented at the 33 rd Annual Meeting of the American Aging Association, St. Petersburg, FL.
Roth, G. S., Ingram, D. K., and Lane, M. A. (1995) Slowing ageing by caloric restriction. Nat. Med. 1(5), 414–415.
Lane, M. A., Ingram, D. K. and Roth, G. S. (1998) 2-D-oxy-D-glucose feeding in rats mimics physiological effects of calorie restriction. J. Anti-Aging Med. 1, 327–337.
Lane, M. A., Ingram, D. K. and Roth, G. S. (2002) The serious search for an antiaging pill. Sci. Am. 24–29.
Duan, W. and Mattson, M. P. (1999) Dietary restriction and 2-deoxyglocse administration improve outcome and reduce degeneration of dopaminergic neurons in Parkinson’s disease. J. Neurosci. Res. 57, 195–206.
Lee, J., Bruce-Keller, A. J., Kruman, Y., Chan, S. L., and Mattson, M. P. (1999) 2-Deoxy-D-Glucose protects hippocampal neurons against excitotoxic and oxidative injury: evidence for involvement of stress proteins. J. Neurosci. Res. 57, 48–61.
Guo, Z., Lane, M. A., and Mattson, M. P. (2001) The glycolysis inhibitor Iiodoacetate protects hippocampal neurons against excitotoxic and oxidative injury: involvement of heat shock proteins and BCL-2. J. Neurochem. 79, 361–370.
Berger, M. M. (2005) Can oxidative damage be treated nutritionally. Clin Nutr. 24, 530–531.
Guarente, L. and Picard, F. (2005) Calorie restrictionthe SIR2 connection. Cell 120, 473–482.
Lee J., Chan S. L., Lu C., Lane M. A., and Mattson M. P. (2002) Phenformin suppresses calcium responses to glutamate and protects hippocampal neurons against excitotoxicity. Exp. Neurol. 175, 161–167.
Anisimov, V. N., Ukraintseva, S. V., Anikin, I. V., et al. (2005) Effect of phentermin and phenformin on biomarkers of aging in rats, Gerontology 51, 19–28.
Roth, G. S., Lane, M. A., and Ingram, D. K. (2005) Caloric restriction mimetics: the next phase. Ann NY Acad. Sci. 1057, 365–371.
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© 2007 Humana Press Inc., Totowa, NJ
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Lane, M.A., Roth, G.S., Ingram, D.K. (2007). Caloric Restriction Mimetics. In: Tollefsbol, T.O. (eds) Biological Aging. Methods in Molecular Biology™, vol 371. Humana Press. https://doi.org/10.1007/978-1-59745-361-5_11
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DOI: https://doi.org/10.1007/978-1-59745-361-5_11
Publisher Name: Humana Press
Print ISBN: 978-1-58829-658-0
Online ISBN: 978-1-59745-361-5
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