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Introduction to Cytokines as Targets for Immunomodulation

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Cytokines in Human Health

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

Abstract

Cytokines play a key role in modulation of immune responses. Cytokine networks regulate lymphocyte turnover, differentiation, and activation. Many different cell types, in addition to immune cells, produce cytokines and express receptors for cytokines. Cell-to-cell communication (cellular “crosstalk”) is maintained via cytokine networks. In disease, these networks undergo imbalance. By measuring amplification or downregulation of cytokine signaling cascades in response to pathological insults or therapeutic interventions, it might be possible to evaluate disease progression or regression. Multiplex formats for cytokine profiling are now available and appear to be especially useful in monitoring cytokine profile alterations in a variety of human diseases.

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Author information

Authors and Affiliations

  1. University of Pittsburgh Cancer Institute, Research Pavilion at the Hillman Cancer Center, Pittsburgh, PA

    Theresa L. Whiteside

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  1. Theresa L. Whiteside
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Editor information

Editors and Affiliations

  1. DyPort Vaccine Company, LLC, Frederick, MD

    Robert V. House

  2. Poison Center and Pharmacovigilance Unit, Lyon Cedex, France

    Jacques Descotes

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© 2007 Humana Press Inc., Totowa, NJ

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Whiteside, T.L. (2007). Introduction to Cytokines as Targets for Immunomodulation. In: House, R.V., Descotes, J. (eds) Cytokines in Human Health. Methods in Pharmacology and Toxicology. Humana Press. https://doi.org/10.1007/978-1-59745-350-9_1

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  • DOI: https://doi.org/10.1007/978-1-59745-350-9_1

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-467-8

  • Online ISBN: 978-1-59745-350-9

  • eBook Packages: Springer Protocols

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