Abstract
With the completion of the Human Genome Project, the microarray technology has evolved into a sophisticated platform by which complex diseases such as cancer, can be studied at the genome, transcriptome, and proteome levels. Here, various microarray platforms, namely comparative genomic hybridization, cDNA, oligonucleotide, and protein-based microarrays are exploited to study genomic copy-number changes in a human cancer cell line and correlate these genomic aberrations with their expression at mRNA and protein levels. The protocols described therein can be assimilated for the study of other human tissues including cancerous ones.
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© 2007 Humana Press Inc., Totowa, NJ
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Al-Mulla, F., Al-Tamimi, R. (2007). Uses of Microarray Platforms in Cancer. In: Rampal, J.B. (eds) Microarrays. Methods in Molecular Biology, vol 382. Humana Press. https://doi.org/10.1007/978-1-59745-304-2_6
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DOI: https://doi.org/10.1007/978-1-59745-304-2_6
Publisher Name: Humana Press
Print ISBN: 978-1-58829-944-4
Online ISBN: 978-1-59745-304-2
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