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Genetics of Wnt Signaling During Early Mammalian Development

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Wnt Signaling

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 468))

Abstract

Proper cell—cell communication is necessary to orchestrate the cell fate determination, proliferation, movement, and differentiation that occurs during the development of a complex, multicellular organism. Members of the Wnt family of secreted signaling molecules regulate these processes in virtually every embryonic tissue and during the homeostatic maintenance of adult tissues. Mammalian genetic studies have been particularly useful in illustrating the specific roles that Wnt signaling pathways play in embryonic development, and in the etiology of diseases such as cancer. This chapter will largely focus on the functional roles that Wnts, signaling through the Wnt/ -catenin pathway, play during early mammalian development.

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Acknowledgments

I apologize to the many authors whose work was omitted due to time and space constraints. I thank Kristin Biris for assistance with manuscript and figure preparation, and members of the laboratory for comments on the manuscript. Work originating in my laboratory was supported by the Intramural Research Program of the National Institutes of Health (NIH), the National Cancer Institute, and the Center for Cancer Research.

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  1. Cancer and Developmental Biology Laboratory, Center for Cancer Research, National Cancer Institute—Frederick, the National Institutes of Health, Frederick, MD, USA

    Terry P. Yamaguchi

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  1. Terry P. Yamaguchi
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  1. University of Melbourne, Parkville, Victoria, VIC 3010, Australia

    Elizabeth Vincan PhD

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© 2008 Humana Press, a part of Springer Science+Business Media, LLC

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Yamaguchi, T.P. (2008). Genetics of Wnt Signaling During Early Mammalian Development. In: Vincan, E. (eds) Wnt Signaling. Methods in Molecular Biology™, vol 468. Humana Press. https://doi.org/10.1007/978-1-59745-249-6_23

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  • DOI: https://doi.org/10.1007/978-1-59745-249-6_23

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-912-3

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