Summary
Both acute and chronic alcohol consumption have significant immunomodulatory effects of which alterations in innate immune functions contribute to impaired antimicrobial defense and inflammatory responses. Blood monocytes, macrophages, and dendritic cells play a central role in innate immune recognition as these cells recognize pathogens, respond with inflammatory cytokine production, and induce antigen-specific T-lymphocyte activation. All of these innate immune cell functions are affected in humans by alcohol intake. Here, we summarize the different effects of acute and chronic alcohol on monocyte, macrophage, and dendritic cell functions in humans and describe methods for separation and functional evaluation of these cell types.
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© 2008 Humana Press, a part of Springer Science+Business Media, LLC
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Szabo, G., Mandrekar, P. (2008). Human Monocytes, Macrophages, and Dendritic Cells: Alcohol Treatment Methods . In: Nagy, L.E. (eds) Alcohol. Methods in Molecular Biology™, vol 447. Humana Press. https://doi.org/10.1007/978-1-59745-242-7_9
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DOI: https://doi.org/10.1007/978-1-59745-242-7_9
Publisher Name: Humana Press
Print ISBN: 978-1-58829-906-2
Online ISBN: 978-1-59745-242-7
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