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Applications of Microarrays and Biochips in Pharmacogenomics

  • Gary Hardiman
Part of the Methods in Molecular Biology™ book series (MIMB, volume 448)

Summary

The complete sequence of the human genome and subsequent intensive searches for polymorphic variations are providing the prerequisite markers necessary to facilitate elucidation of the genetic variability in drug responses. Improvements in the sensitivity and precision of DNA microarrays permit a detailed and accurate scrutiny of the human genome. These advances have the potential to significantly improve health care management by improving disease diagnosis and targeting molecular therapy. Pharmacogenetic approaches, in limited use today, will become an integral part of therapeutic monitoring and health management, permitting patient stratification in advance of treatments, with the potential to eliminate adverse drug reactions. In this chapter, the current state of biochip technology is discussed, and recent applications in the arena of clinic diagnostics are explored.

Keywords

AmpliChip biochips microarrays P450 pharmacogenetics 

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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Gary Hardiman
    • 1
  1. 1.BIOGEM, and Department of MedicineUniversity of California San DiegoLa JollaUSA

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