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Electroporation Protocols pp 393–404Cite as

Hepatocyte Growth Factor Gene Therapy for Hypertension

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Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 423))

Abstract

Hepatocyte growth factor (HGF) has mitogenic, motogenic, and morphogenic biological activities as well as helps in regenerating various tissues. In cardiovascular organs, HGF was reported to have anti-apoptotic, anti-fibrotic, and vasodilating effects. HGF has close relationships with hypertension, arteriosclerosis, and heart failure. HGF enhances renal regeneration and suppresses the progression of hypertension. Intramuscular electroporation of the therapeutic gene is a simple, economic, and low toxic method compared with systemic administration of the purified proteins or peptides. We outline the technique of intramuscular electroporation of HGF gene as a remedy for hypertension.

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Acknowledgments

This work was supported by grant-in-aid for Scientific Research 11670729 and 14570709 from the Ministry of Education, Culture, Sport, Science, and Technology of Japan and by the program for promotion of Fundamental Studies in Health Sciences of the Pharmaceuticals and Medical Devices Agency (PMDA).

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Authors and Affiliations

  1. Department of Cardiovascular Dynamics, Research Institute, National Cardiovascular Center, Suita, Japan

    Kazuo Komamura, Jun-ichi Miyazaki, Enyu Imai, Kunio Matsumoto, Toshikazu Nakamura & Masatsugu Hori

Authors
  1. Kazuo Komamura
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  2. Jun-ichi Miyazaki
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  3. Enyu Imai
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  4. Kunio Matsumoto
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  5. Toshikazu Nakamura
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  6. Masatsugu Hori
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Editors and Affiliations

  1. Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA

    Shulin Li

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© 2008 Humana Press

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Komamura, K., Miyazaki, Ji., Imai, E., Matsumoto, K., Nakamura, T., Hori, M. (2008). Hepatocyte Growth Factor Gene Therapy for Hypertension. In: Li, S. (eds) Electroporation Protocols. Methods in Molecular Biology™, vol 423. Humana Press. https://doi.org/10.1007/978-1-59745-194-9_31

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  • DOI: https://doi.org/10.1007/978-1-59745-194-9_31

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-877-5

  • Online ISBN: 978-1-59745-194-9

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