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Mobilization of Hematopoietic Stem and Progenitor Cells in Mice

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Hematopoietic Stem Cell Protocols

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 430))

Summary

Animal models have added significantly to our understanding of the mechanism(s) of hematopoietic stem and progenitor cell (HSPC) mobilization. Such models suggest that changes in the interaction between the HSPC and the hematopoietic microenvironmental ‘niche’ (cellular and extracellular components) are critical to the process. The increasing availability of recombinant proteins (growth factors, cytokines, chemokines), antibodies, drugs (agonists and antagonists), and mutant and genetically modified animal models [gene knock-in (KI) and knock-out (KO)] continue to add to the tools available to better understand and manipulate mobilization processes.

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Acknowledgments

The authors thank the animal handling, technical, and veterinary staff that assisted with these studies. SNR thanks Dr. J. Graham Sharp, University of Nebraska Medical Center, Omaha, Nebraska, for his support and advice with the preparation of this chapter.

Author information

Authors and Affiliations

  1. University of Texas, MD Anderson Cancer Center, Houston, TX

    Simon N. Robinson

  2. Department of Stem Cell Biology, University Medical Center Groningen, the Netherlands

    Ronald P. van Os

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  1. Simon N. Robinson
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  2. Ronald P. van Os
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Editors and Affiliations

  1. Department of Medicine, Division of Hematology & Oncology, Center for Stem Cell and Regenerative Medicine, Case Western Reserve University, Cleveland, OH, USA

    Kevin D. Bunting

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© 2008 Humana Press, a part of Springer Science+Business Media, LLC

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Robinson, S.N., van Os, R.P. (2008). Mobilization of Hematopoietic Stem and Progenitor Cells in Mice. In: Bunting, K.D. (eds) Hematopoietic Stem Cell Protocols. Methods in Molecular Biology™, vol 430. Humana Press. https://doi.org/10.1007/978-1-59745-182-6_3

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  • DOI: https://doi.org/10.1007/978-1-59745-182-6_3

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-868-3

  • Online ISBN: 978-1-59745-182-6

  • eBook Packages: Springer Protocols

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