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Immunobiology of Neural Xenotransplantation

  • Protocol
Neural Transplantation Methods

Part of the book series: Neuromethods ((NM,volume 36))

Abstract

The field of neural transplantation has rapidly progressed during the past two decades. Since the first published observations on the functional effects of transplanted fetal dopamine (DA) neurons in rodents (Perlow et al., 1979; Björklund and Stenevi, 1979), there are now several ongoing clinical trials to assess the efficacy of transplanting human fetal neurons for the treatment of patients with Parkinson’s disease (PD) (Freed et al., 1992; Widner et al., 1992) and Huntington’s disease (HD) (Kopyov et al., 1996). However, a major limitation to the widespread clinical application of this approach is the inability to obtain consistently suitable specimens for transplantation, and the ethical concerns of using human fetal tissue. Consequently, the use of donor tissue from other species as xenografts has been proposed as an alternative to the use of human fetal allografts.

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Authors and Affiliations

  1. Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, MN

    Walter C. Low, C. Dirk Keene & Marcus A. Westerman

  2. Department of Neurosurgery, Lions Research Building, University of Minnesota Medical School, Minneapolis, MN

    Wei-Ming Duan & Hsiao-Tzu Ni

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  1. Walter C. Low
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  2. Wei-Ming Duan
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  3. C. Dirk Keene
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  4. Hsiao-Tzu Ni
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  5. Marcus A. Westerman
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Editors and Affiliations

  1. University of Cambridge, Cambridge, UK

    Stephen B. Dunnett

  2. Cardiff University, Cardiff, Wales, UK

    Stephen B. Dunnett

  3. University of Saskatchewan, Saskatoon, Canada

    Alan A. Boulton

  4. University of Alberta, Edmonton, Canada

    Glen B. Baker

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Low, W.C., Duan, WM., Keene, C.D., Ni, HT., Westerman, M.A. (2000). Immunobiology of Neural Xenotransplantation. In: Dunnett, S.B., Boulton, A.A., Baker, G.B. (eds) Neural Transplantation Methods. Neuromethods, vol 36. Humana Press. https://doi.org/10.1007/978-1-59259-690-4_23

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  • DOI: https://doi.org/10.1007/978-1-59259-690-4_23

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-793-9

  • Online ISBN: 978-1-59259-690-4

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