Abstract
In my contributions to this book I shall consider proteins and peptides as functional biological units, rather than as chemical compounds. I shall try to show that, from the point of view of a biologist, proteins should not be considered as individual entities, but rather as components of complex interacting cyclical control systems that involve not only multitudes of other proteins, but also non-protein-components of cells and of the extracellular environment. I have in mind, for example, the phospholipids of the cell membrane, nonproteinacious chemical messengers (steroids and neurotransmitters), and drugs and toxins of low molecular weight.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
W. Y. Cheung, Science 207, 19–27 (1980).
J. Kallos, Nature 265, 705–710 (1977).
H. Tamir, A. Klein, and M. M. Rapport, J. Neurochem. 26, 871–878 (1976).
M. D. Gershon, K. P. Liu, S. E. Karpiak, and H. Tamir, J, Neuroscience 3, 1901–1911 (1983).
P. Englebienne, Molec. Asp. med. 7, 313–396 (1984).
L. L. Iverson, Trends Neurosci. 6, 293–294 (1983).
L. W. Swanson, Trends Neurosci. 6, 294–295 (1983).
M. E. Hadley, Endocrinology Prenctice Hall, New Jersey (1984).
P. J. Thomas, Molec. Asp. Med. 5, 1–61 (1982).
A. Peters, S. L. Palay, and H. de F. Webster, The Fine Structure of the Nervous System W. B. Saunders, Philadelphia, London, Toronto (1976), p. 36.
A. Goth, Medical Pkarrnacology Mosby, St. Louis, Toronto, London, p. 155–122 (1981).
P. Greengard, Nature 260, 101–108 (1976).
L. L. Iverson, Biockem. Pkurmucol. 23, 1927–1233 (1974).
E. E. Muller, G. Nistico, and U. Scapagnini, Neurotrunsmitter and Anterior Pituitary Function Academic, London (1977), pp. 102–115.
K. Krvjevic, Pkysiol. Rev. 54, 418–540 (1974).
J. M. Lundberg and T. Hokfelt, Trends Neurosci. 6, 325–332 (1983).
J. Parascandol, in Towards Understanding Receptors (J. W. Lamble, ed.) Elsevier/North Holland (1981), pp. 1–8.
P. J. Thomas, J. Endocrinul. 57, 333–359 (1973).
K. Sterling, N. Eng. J. Med. 300, 117–123; 173-177 (1979).
M. R. Haussler, M. R. Hughes, T. McCain, and S. A. Pike, in Molecular Endocrinology (I. MacIntyre and M. Szelke, eds.) Elsevier/North Holland (1977), pp. 101–116.
W. J. King and G. L. Green, Nature 307, 745–747 (1984).
W. V. Welshons, M. E. Lieberman, and J. Gorski, Nature 307, 747–749 (1984).
D. Colquhoun, in Towards Understanding Receptors (J. W. Lamble, ed.) Elsevierl/North Holland (1981), pp. 17–27.
E. W. Sutherland, T. W. Rall, and T. Menon, J. Biol. Chem. 237, 1220–1222 (1962).
R. Lim, K. Mitsunobu, and W. K. P. Li, Exp. Cell Res. 79, 243–246 (1973).
D. L. Schapiro, Nature 241, 203–204 (1973).
Y. H. Erlich, E. G. Brunngraber, P. K. Sinha, and K. N. Prasad, Nature 265, 238–240 (1977).
R. Siete, J. Luciano-Vuillet Leonetti, and M. Vio, Brain Res. 124, 41–51 (1977).
J. Zwiller, C. Goridis, J. Ciesielski-Treska, and P. Maridel, J. Neurochem. 29, 273–278 (1977).
T. W. Stone, D. A. Taylor, and F. E. Bloom, Science 187, 845–846 (1975).
R. J. Coffey, E. M. Hadden, C. Lopez, and J. W. Hadden, Adv. Cyclic Nucleotide Res. 9, 661–676 (1978).
W. G. George, G. M. Rodgers, and L. A. White, Adv. CycIic Nucleotide Res. 9, 517–523 (1978).
W. J. Thomson and W. W. Appleman, Biochemistry 10, 311–316, (1971).
M. Williams and R. Rodnight, Prog. Neurobiof. 8, 183–240.
A. L. Lehninger, Biochemistry Worth Publishers, New York (1975).
A. Peters, S. L. Palay, and H. de F. Webster, The Fine Structure of the Nervous System Saunders, Philadelphia, London, Toronto (1976), pp. 107–112.
B. Pickering, Essays in Biochemistry 14, 45–81 (1978).
J-L. Popot and J-P. Changeux, Physiol. Rev. 64, 1162–1238 (1984).
M. L. Barbaccia, D. M. Chung, and E. Costa, in Regulatory Peptides; From Molecular Biology fo Function (M. Costa and E. Trabuchi, eds.) Raven, New York (1982), pp. 511–518.
J. Havrankova, M. Brownstein, and J. Roth, diabetologica 20, 268–273 (1981).
J. Havrankovaa, D. Schnechel, J. Roth, and M. Brownstein, Proc. Natl. Acad. Sci USA 73, 5737–5741 (1978).
B. Bohus, Pharmacology 18, 113–122 (1979).
D. De Weid, Trends Neurosci. 2, 79–82 (1979).
J. M. Moeglan, A. Audibert, M. Timisit-Berthier, J. C. Oliveros, and M. K. Jandali, in Neuroendocrinology; Biological and Clinical Aspects (A. Pollen and R. M. MacLeod, eds.) Academic, London (1979), pp. 47–57.
B. S. McEwen, Trends Neurosci. 6, 22–26 (1985).
0. A. Amechi, P. J. Butterworth, and P. J. Thomas, Brain Res. 342, 158–161 (1985).
C. Le Blond, R. Powell, G. Karkiulakis, S. Morris, and P. J. Thomas, J. Endocrinol. 95, 137–145 (1982).
J-P Changeux and A. Danchin, Nature 264, 705–710 (1980).
M. Hirata and J. Axelrod, J. Science 209, 1082–1087 (1980).
M. J. Berridge, in Towards Understanding Receptors (J. W. Lamble, ed.) 1, 122–131 (1981).
A. Biegon and B. S. McEwen, J. Neuroscience 2, 199–202 (1982).
G. J. Blackwell, R. Carnuccio, M. Di Rosa, R. J. Flower, L. Parente, and P. Perisco, Nature 287, 147–149 (1980).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Humana Press Inc.
About this protocol
Cite this protocol
Thomas, P.J. (1988). Characteristics of Proteins and Peptides In Situ . In: Franks, F. (eds) Characterization of Proteins. Biological Methods. Humana Press. https://doi.org/10.1007/978-1-59259-437-5_6
Download citation
DOI: https://doi.org/10.1007/978-1-59259-437-5_6
Publisher Name: Humana Press
Print ISBN: 978-0-89603-109-8
Online ISBN: 978-1-59259-437-5
eBook Packages: Springer Book Archive