Abstract
The rapid evolution of monoclonal antibody (MAb) technology has resulted in an ever-growing repertoire of proteins becoming accessible for study using immunohistochemical techniques. Nuclear antigens represent a class of proteins of increasing significance and diversity; they are intimately associated with important cellular functions, such as cell-cycle regulation and DNA replication and repair. The control of growth of any tissue is a complex series of coordinated mechanisms. Deregulation of this control is a fundamental feature of most common neoplasms. Knowledge of proliferative activity in human tumors should give important information for evaluating both biological behavior and potential treatment strategies.
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© 1998 Humana Press Inc., Totowa, NJ
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Wilson, G.D. (1998). Flow Cytometric Detection of Proliferation-Associated Antigens, PCNA and Ki-67. In: Pound, J.D. (eds) Immunochemical Protocols. Methods in Molecular Biology™, vol 80. Humana Press. https://doi.org/10.1007/978-1-59259-257-9_36
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DOI: https://doi.org/10.1007/978-1-59259-257-9_36
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