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The CRISPR System and Cancer Immunotherapy Biomarkers

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Biomarkers for Immunotherapy of Cancer

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2055))

Abstract

Recent advances in cancer immunotherapy have shed new light on the possibility to cure most, if not all, cancer patients with further development of various treatment options. The emergency of a new genome editing tool, the clustered regularly interspaced short palindromic repeats (CRISPR) technology, revolutionized the biomedical research field. We envision application of the CRISPR technology in cancer research, diagnosis, and therapy will markedly speed up the development of new treatment options for cancer patients. The CRISPR system and its applications in biomedical research will be discussed with an emphasis on cancer immunotherapy and biomarker development.

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Acknowledgments

We thank Bing C. Wang, Francesco Marincola, and other colleagues of Refuge Biotechnologies for their support.

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Authors and Affiliations

  1. Refuge Biotechnologies Inc., Menlo Park, CA, USA

    Vitaly Balan & Jianbin Wang

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  1. Vitaly Balan
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  2. Jianbin Wang
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Correspondence to Jianbin Wang .

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  1. NIH, National Cancer Institute, Bethesda, MD, USA

    Magdalena Thurin

  2. Nanostring Technologies, Seattle, WA, USA, ESSA Pharma, South San Francisco, CA, USA

    Alessandra Cesano

  3. Refuge Biotechnologies, Menlo Park, CA, USA

    Francesco M. Marincola

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Balan, V., Wang, J. (2020). The CRISPR System and Cancer Immunotherapy Biomarkers. In: Thurin, M., Cesano, A., Marincola, F. (eds) Biomarkers for Immunotherapy of Cancer. Methods in Molecular Biology, vol 2055. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9773-2_14

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