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Focal and Restricted Traumatic Injury Models in the Rodent Brain: Limitations, Possibilities, and Challenges

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Animal Models of Neurotrauma

Part of the book series: Neuromethods ((NM,volume 149))

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Abstract

Animal models of traumatic brain injury are primarily utilized for the purpose of either (a) conducting basic research—for instance regarding the neurocognitive organization of the brain or (b) the development and evaluation of therapeutic interventions—such as pharmacological and behavioral methods as well as environmental manipulations. While studies focusing on development of therapeutic methods may primarily call for the use of more “ecologically valid” models, studies of the neurocognitive organization of the brain may primarily benefit from the use of focal and anatomically restricted lesions. The present chapter focuses on such models. The primary focus of the chapter is a model in which the fimbria-fornix is selectively transected and hippocampal function consequently severely impaired. The method of this transection is described, and the neural and functional consequences of the lesion are reviewed. In order to best utilize such focal lesions in the analysis of neurocognitive organization additional methods are needed. These methods include combined and simultaneously inflicted focal lesions as well as the use of both organic and behavioral “challenge” techniques. Such an approach enables a deeper understanding of the mediating mechanisms at the level of anatomical structure and/or neurotransmitter system and prevents premature conclusions regarding the neurocognitive organization.

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Acknowledgements

The present study was supported by a grant from the Danish Council for Independent Research.

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Authors and Affiliations

  1. The Unit for Cognitive Neuroscience, Department of Psychology, University of Copenhagen, Copenhagen K, Denmark

    Jesper Mogensen & Hana Malá

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  1. Jesper Mogensen
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  2. Hana Malá
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Correspondence to Jesper Mogensen .

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  1. Experimental Traumatology, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden

    Mårten Risling

  2. Division of Vehicle Safety, Department of Mechanics and Maritime Sciences, Chalmers University of Technology, Gothenburg, Sweden

    Johan Davidsson

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Mogensen, J., Malá, H. (2019). Focal and Restricted Traumatic Injury Models in the Rodent Brain: Limitations, Possibilities, and Challenges. In: Risling, M., Davidsson, J. (eds) Animal Models of Neurotrauma. Neuromethods, vol 149. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9711-4_2

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  • DOI: https://doi.org/10.1007/978-1-4939-9711-4_2

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