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Real-Time Sensing with Patterned Plasmonic Substrates and a Compact Imager Chip

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Biomimetic Sensing

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2027))

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Abstract

Optical sensing is an important research field due to its proven ability to be extremely sensitive, nondestructive, and applicable to sensing a wide range of chemical, thermal, electric, or magnetic phenomena. Beyond traditional optical sensors that often rely on bulky setups, plasmonic nanostructures can offer many advantages based on their sensitivity, compact form, cost-effectiveness, multiplexing compatibility, and compatibility with many standard semiconductor nanofabrication techniques. In particular, plasmon-enhanced optical transmission through arrays of nanostructured holes has led to the development of a new generation of optical sensors. In this chapter we present a simple fabrication technique to use plasmonic nanostructures as compact sensors. We position the nanohole array, an LED illumination source, and a spacer layer directly on top of a standard complementary metal–oxide–semiconductor (CMOS) imager chip. This setup is a viable sensor platform in both liquid and gas environments. These devices could operate as low-cost sensors for environmental monitoring, security, food safety, or monitoring small-molecule binding to extract affinity information and binding constants.

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Acknowledgments

The authors thank Phil Minell and James Myrick (US Enginewing) for collaborative discussion and support. Parts of this research were also supported by the Minnesota Space Grant Consortium (MnSGC), part of the NASA-funded National Space Grant College and Fellowship Program.

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Authors and Affiliations

  1. Department of Physics and Engineering, Bethel University, St. Paul, MN, USA

    Spencer T. Seiler, Isabel S. Rich & Nathan C. Lindquist

Authors
  1. Spencer T. Seiler
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  2. Isabel S. Rich
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  3. Nathan C. Lindquist
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Corresponding author

Correspondence to Nathan C. Lindquist .

Editor information

Editors and Affiliations

  1. Departments of Bioengineering and Chemical Engineering, Northeastern University, Boston, MA, USA

    Jessica E. Fitzgerald

  2. Departments of Chemical Engineering, Bioengineering, Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA

    Hicham Fenniri

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Seiler, S.T., Rich, I.S., Lindquist, N.C. (2019). Real-Time Sensing with Patterned Plasmonic Substrates and a Compact Imager Chip. In: Fitzgerald, J., Fenniri, H. (eds) Biomimetic Sensing. Methods in Molecular Biology, vol 2027. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9616-2_8

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  • DOI: https://doi.org/10.1007/978-1-4939-9616-2_8

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-9615-5

  • Online ISBN: 978-1-4939-9616-2

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