Abstract
Photochromic molecules can respond to external stimulations and undergo reversible conversion between different chemical structures, providing one photochromic molecule with multiple recognition states for targeting compounds. Here we design a facile sensor microchip with only one photochromic molecule (spirooxazine) to discriminate multiplex metal ions. The sensor chip performs in dark, ultraviolet, or visual stimulation, resulting in different molecular states of spirooxazine-metallic coordination and patterned fluorescent signals for analysis. By using this sensor microchip, 11 metal ions are discriminated. Furthermore, mineral water of 16 different brands and metal ions in human serum are distinguished.
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Acknowledgments
This work was supported by the National Nature Science Foundation (Grant Nos. 51203166, 51473172, and 51473173), 973 Program (Nos. 2013CB933004), and the “Strategic Priority Research Program” of the Chinese Academy of Sciences (Grant No. XDA09020000). The Chinese Academy of Science is gratefully acknowledged.
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Qin, M., Li, F., Song, Y. (2019). A Photochromic Sensor Microchip for High-Performance Multiplex Metal Ion Detection. In: Fitzgerald, J., Fenniri, H. (eds) Biomimetic Sensing. Methods in Molecular Biology, vol 2027. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9616-2_4
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DOI: https://doi.org/10.1007/978-1-4939-9616-2_4
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