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An Update on Artemisinin Resistance

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Malaria Control and Elimination

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2013))

Abstract

While the precise mode of action of artemisinin (ART) derivatives remains obscure, it is nonetheless commonly accepted that ART generates reactive oxygen intermediates that contribute to cell death. Also, numerous studies confirm that point mutations in the propeller domain of K13 protein play a key role in resistance to ART derivatives. Because of its homology with the KEAP1 protein, it is thought that this protein may have a role in the polyubiquitination of proteins and that its alteration may cause resistance of young parasite stages to the drug. In this chapter, we present our current knowledge of K13-related resistance to ART and its spread in Southeast Asia and discuss its possible emergence and/or diffusion in Africa.

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Author information

Authors and Affiliations

  1. INSERM 1016, Institut Cochin, Université Paris Descartes, Paris, France

    Frédéric Ariey

  2. Service de Parasitologie-Mycologie, Hôpital Cochin, Paris, France

    Frédéric Ariey

  3. Biology of Host-Parasite Interactions Unit, Malaria Genetic and Resistance Group, Pasteur Institute, Paris, France

    Didier Ménard

Authors
  1. Frédéric Ariey
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  2. Didier Ménard
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Correspondence to Frédéric Ariey .

Editor information

Editors and Affiliations

  1. INSERM 1016 Institut Cochin, Service de Parasitologie-Mycologie, Université Paris Descartes, Hôpital Cochin, Paris, France

    Frédéric Ariey

  2. Faculté de Médecine, AP-HP, Sorbonne Université, Groupe Hospitalier Pitié-Salpêtrière, Paris, France

    Frédérick Gay

  3. Malaria Infection and Immunity Unit, Institut Pasteur, Paris, France

    Robert Ménard

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Ariey, F., Ménard, D. (2019). An Update on Artemisinin Resistance. In: Ariey, F., Gay, F., Ménard, R. (eds) Malaria Control and Elimination. Methods in Molecular Biology, vol 2013. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9550-9_10

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  • DOI: https://doi.org/10.1007/978-1-4939-9550-9_10

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-9549-3

  • Online ISBN: 978-1-4939-9550-9

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