Abstract
Protein S-palmitoylation is increasingly recognized as an important posttranslational modification, present in all eukaryotic organisms, involved in the regulation of many biological processes. The SwissPalm database centralizes the large and increasing number of published palmitoyl-proteome datasets, provides tools to compare them, and includes curated data from the literature on the identification and analysis of palmitoylated proteins. SwissPalm 2 provides an updated version, with 38 palmitoyl-proteomes at the time of release, from 17 different species, and new features such as the inclusion of orthologs.
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Acknowledgments
This work benefited from funding from the European Research Council under the European Union’s Seventh Framework Programme (FP/2007-2013)/ERC Grant Agreement no. 340260—PalmERa. This work was also supported by grants from the Swiss National Science Foundation (to G.v.d.G), the Swiss National Centre of Competence in Research (NCCR) Chemical Biology, and the Swiss SystemsX.ch initiative evaluated by the Swiss National Science Foundation (LipidX) (to G.v.d.G). M.B. was a recipient from an EMBO Long Term Fellowship.
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Blanc, M., David, F.P.A., van der Goot, F.G. (2019). SwissPalm 2: Protein S-Palmitoylation Database. In: Linder, M. (eds) Protein Lipidation. Methods in Molecular Biology, vol 2009. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9532-5_16
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DOI: https://doi.org/10.1007/978-1-4939-9532-5_16
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