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Colonic Delivery of H2S Donors for Studying Cardiovascular Effects of H2S in Rats

  • Marcin UfnalEmail author
  • Tomasz Hutsch
Protocol
  • 384 Downloads
Part of the Methods in Molecular Biology book series (MIMB, volume 2007)

Abstract

There is evidence that H2S produced in the colon may contribute to the control of the circulatory system. This chapter describes a technique of cardiovascular measurements in anesthetized rats subjected to intracolonic administration of H2S donor. The intracolonic administration is performed via polyurethane catheter inserted per rectum into the colon.

Key words

Hydrogen sulfide Colon i.c. Cardiovascular diseases Gut Bacteria 

References

  1. 1.
    Tomasova L, Dobrowolski L, Jurkowska H, Wrobel M, Huc T, Ondrias K, Ostaszewski R, Ufnal M (2016) Intracolonic hydrogen sulfide lowers blood pressure in rats. Nitric Oxide 60:50–58CrossRefGoogle Scholar
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    Tomasova L, Konopelski P, Ufnal M (2016) Gut bacteria and hydrogen sulfide: the new old players in circulatory system homeostasis. Molecules 21(11)CrossRefGoogle Scholar
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    Konopelski P, Ufnal M (2016) Electrocardiography in rats: a comparison to human. Physiol Res 65(5):717–725PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Laboratory of Centre for Preclinical Research, Department of Experimental Physiology and PathophysiologyMedical University of WarsawWarsawPoland

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