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The Relaxant Mechanisms of Hydrogen Sulfide in Corpus Cavernosum

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Vascular Effects of Hydrogen Sulfide

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2007))

Abstract

In several animal and human studies, the contribution of the endothelium, nitric oxide/soluble guanosine monophosphate (NO/cGMP) pathway, adenylyl cyclase, phosphodiesterase (PDE), potassium (K+) channels, L-type calcium channels, Na+-K+-ATPase, muscarinic acetylcholine receptors, RhoA/Rho-kinase pathway, and cyclooxygenase (COX)/arachidonic acid cascade on the relaxant mechanism of l-cysteine/H2S pathway in corpus cavernosum has been investigated. In this chapter the relaxant mechanisms of H2S in corpus cavernosum is discussed with data available in the current relevant literature. Also, in vitro experimental procedure for mice corpus cavernosum which used to investigate the relaxant effect of H2S is given in detail.

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Authors and Affiliations

  1. Department of Pharmacology, Pharmacy Faculty, Cukurova University, Adana, Turkey

    Fatma Aydinoglu

  2. Department of Pharmacology, Medical Faculty, Cukurova University, Adana, Turkey

    Nuran Ogulener

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  1. Fatma Aydinoglu
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  2. Nuran Ogulener
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  1. Department of Pathophysiology, Medical University, Lublin, Poland

    Jerzy Bełtowski

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Aydinoglu, F., Ogulener, N. (2019). The Relaxant Mechanisms of Hydrogen Sulfide in Corpus Cavernosum. In: Bełtowski, J. (eds) Vascular Effects of Hydrogen Sulfide. Methods in Molecular Biology, vol 2007. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9528-8_10

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  • DOI: https://doi.org/10.1007/978-1-4939-9528-8_10

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