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Methods of Fabrication of Chitosan-Based Nano-in-Microparticles (NMPs)

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Book cover Pharmaceutical Nanotechnology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2000))

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Abstract

Chitosan nano-in-microparticles (NMPs) are promising carrier systems that have gained recently more interest aiming to combine advantages of both the nano- and microsystems. They have been employed for various purposes including sustained pulmonary delivery of drugs and pulmonary delivery of peptides, proteins, or genes or as injectable scaffolds for simultaneous delivery of stem cells and supporting growth factors. Among these delivery systems, chitosan was a common ingredient due to its biocompatibility, biodegradability, and ability to sustain the release of drugs and improving their bioavailability. Here we introduce a method for the development of chitosan self-assembly nanoparticles and the incorporation of these nanoparticles into chitosan microparticles via spray drying.

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Author information

Authors and Affiliations

  1. Center for Materials Science, Zewail City of Science and Technology, University of Science and Technology (UST), Giza, Egypt

    Ibrahim M. El-Sherbiny & Amr Hefnawy

Authors
  1. Ibrahim M. El-Sherbiny
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  2. Amr Hefnawy
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Corresponding author

Correspondence to Ibrahim M. El-Sherbiny .

Editor information

Editors and Affiliations

  1. Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, Glendale, AZ, USA

    Volkmar Weissig

  2. Nanomedicine Center of Excellence in Translational Cancer Research, Midwestern University, Glendale, AZ, USA

    Tamer Elbayoumi

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El-Sherbiny, I.M., Hefnawy, A. (2019). Methods of Fabrication of Chitosan-Based Nano-in-Microparticles (NMPs). In: Weissig, V., Elbayoumi, T. (eds) Pharmaceutical Nanotechnology. Methods in Molecular Biology, vol 2000. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9516-5_8

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  • DOI: https://doi.org/10.1007/978-1-4939-9516-5_8

  • Published:

  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-9515-8

  • Online ISBN: 978-1-4939-9516-5

  • eBook Packages: Springer Protocols

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