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Preparation and Characterization of Solid Lipid Nanoparticles-Based Gel for Topical Delivery

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Book cover Pharmaceutical Nanotechnology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2000))

Abstract

Solid lipid nanoparticles (SLNs) have been extensively investigated for effective delivery of both hydrophilic and lipophilic drugs by topical route. There are several scalable techniques for the preparation of SLNs such as homogenization, microemulsion template, and solvent emulsification diffusion. This chapter describes step-wise methodology for the preparation and characterization of SLNs using solvent emulsification diffusion method. Tretinoin, a lipophilic entity, was chosen as a model drug. The critical aspects and the important interpretations with respect to the preparation and characterization of SLNs are reported in “Notes” section.

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Author information

Authors and Affiliations

  1. Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, India

    Vandana B. Patravale & Amit G. Mirani

Authors
  1. Vandana B. Patravale
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  2. Amit G. Mirani
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Corresponding author

Correspondence to Vandana B. Patravale .

Editor information

Editors and Affiliations

  1. Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, Glendale, AZ, USA

    Volkmar Weissig

  2. Nanomedicine Center of Excellence in Translational Cancer Research, Midwestern University, Glendale, AZ, USA

    Tamer Elbayoumi

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Patravale, V.B., Mirani, A.G. (2019). Preparation and Characterization of Solid Lipid Nanoparticles-Based Gel for Topical Delivery. In: Weissig, V., Elbayoumi, T. (eds) Pharmaceutical Nanotechnology. Methods in Molecular Biology, vol 2000. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9516-5_20

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  • DOI: https://doi.org/10.1007/978-1-4939-9516-5_20

  • Published:

  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-9515-8

  • Online ISBN: 978-1-4939-9516-5

  • eBook Packages: Springer Protocols

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