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HPLC Enantioseparation on Cyclodextrin-Based Chiral Stationary Phases

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Chiral Separations

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1985))

Abstract

As one of the commonly used chiral separation materials, cyclodextrin-based chiral stationary phases (CD-CSP) have been developed rapidly in the past 30 years. A large number of CD-CSPs have been designed and applied for enantioseparation in high-performance liquid chromatography (HPLC). The development of novel CD-CSPs focuses on two aspects: the immobilization chemistry and the functionalization of the CD skeleton. Although such studies are not regarded as the prime research topic in analytical chemistry, there are still many recent works pushing this research forward tardily. In this chapter, the fabrication procedure of a triazole-bridged duplex CD-CSP and its application to HPLC enantioseparations is described.

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Acknowledgments

The financial support from the National Natural Science Foundation of China (no. 21575100), Tianjin Research Program of Application Foundation and Advanced Technology (17JCYBJC20500, 18JCZDJC37500), and National Program on Key Basic Research Project (2015CB856505) are gratefully acknowledged.

Author information

Authors and Affiliations

  1. Department of Chemical Engineering, Chengde Petroleum College, Chengde, Hebei, People’s Republic of China

    Xiaoxuan Li

  2. Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science, Tianjin University, Tianjin, People’s Republic of China

    Yong Wang

  3. Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, People’s Republic of China

    Yong Wang

Authors
  1. Xiaoxuan Li
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  2. Yong Wang
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Corresponding author

Correspondence to Yong Wang .

Editor information

Editors and Affiliations

  1. Department of Pharmaceutical Chemistry, University of Jena, Jena, Germany

    Gerhard K. E. Scriba

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Li, X., Wang, Y. (2019). HPLC Enantioseparation on Cyclodextrin-Based Chiral Stationary Phases. In: Scriba, G.K.E. (eds) Chiral Separations. Methods in Molecular Biology, vol 1985. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9438-0_9

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  • DOI: https://doi.org/10.1007/978-1-4939-9438-0_9

  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-9437-3

  • Online ISBN: 978-1-4939-9438-0

  • eBook Packages: Springer Protocols

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