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Enantioseparation of Selected Imidazole Drugs Using Dual Cyclodextrin-Modified Micellar Electrokinetic Chromatography

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Book cover Chiral Separations

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1985))

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Abstract

Particular attention has been paid to capillary electrophoresis as versatile and environmentally friendly approach for enantioseparations of a wide spectrum of compounds. Cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC) is a method of choice to provide effective separation toward hydrophobic and uncharged stereoisomers. The chiral discrimination of the solutes relies upon the partitioning between a given CD in the aqueous phase and micelles formed from a surfactant. Synergistic combinations of chiral selectors, surfactant, and modifier contribute to successful enantioseparations of the enantiomers. In this chapter, an application of CD-MEKC for the enantioseparation of selected imidazole drugs employing a dual CDs system is described.

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Acknowledgments

This work was supported by the Fundamental Research Grant Scheme from the Ministry of Higher Education (Malaysia) under vote number R.J130000.7826.3F262 (78314) and the National Science Foundation awarded by the Ministry of Science, Technology and Innovation (Malaysia) to S.M. Abdul Wahib is much appreciated.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Johor Bahru, Johor, Malaysia

    Wan Aini Wan Ibrahim, Siti Munirah Abd Wahib & Mohd Marsin Sanagi

  2. Faculty of Mathematics and Natural Sciences, Department of Chemistry, Universitas Jenderal Soedirman, Purwokerto, Indonesia

    Dadan Hermawan

Authors
  1. Wan Aini Wan Ibrahim
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  2. Siti Munirah Abd Wahib
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  3. Dadan Hermawan
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  4. Mohd Marsin Sanagi
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Corresponding author

Correspondence to Wan Aini Wan Ibrahim .

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Editors and Affiliations

  1. Department of Pharmaceutical Chemistry, University of Jena, Jena, Germany

    Gerhard K. E. Scriba

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Ibrahim, W.A.W., Wahib, S.M.A., Hermawan, D., Sanagi, M.M. (2019). Enantioseparation of Selected Imidazole Drugs Using Dual Cyclodextrin-Modified Micellar Electrokinetic Chromatography. In: Scriba, G.K.E. (eds) Chiral Separations. Methods in Molecular Biology, vol 1985. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9438-0_24

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  • DOI: https://doi.org/10.1007/978-1-4939-9438-0_24

  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-9437-3

  • Online ISBN: 978-1-4939-9438-0

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