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Application of Dual-Cyclodextrin Systems in Capillary Electrophoresis Enantioseparations

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Chiral Separations

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1985))

Abstract

The enantioseparation of acidic and neutral compounds can be successfully achieved in capillary electrophoresis (CE) using dual-cyclodextrin (CD) systems. This chapter describes how to separate the enantiomers of acidic or neutral substances using dual-CD systems made up of a negatively charged CD derivative, i.e., sulfobutyl-β-CD or carboxymethyl-β-CD, in combination with a neutral one, namely heptakis(2,3,6-tri-O-methyl)-β-CD. An acidic compound (carprofen) and a weakly acidic drug (pentobarbital) were selected as model compounds.

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Authors and Affiliations

  1. Laboratory for the Analysis of Medicines, Department of Pharmaceutical Sciences, CIRM, Quartier Hôpital, University of Liège, Liège, Belgium

    Anne-Catherine Servais & Marianne Fillet

Authors
  1. Anne-Catherine Servais
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  2. Marianne Fillet
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Corresponding author

Correspondence to Marianne Fillet .

Editor information

Editors and Affiliations

  1. Department of Pharmaceutical Chemistry, University of Jena, Jena, Germany

    Gerhard K. E. Scriba

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Servais, AC., Fillet, M. (2019). Application of Dual-Cyclodextrin Systems in Capillary Electrophoresis Enantioseparations. In: Scriba, G.K.E. (eds) Chiral Separations. Methods in Molecular Biology, vol 1985. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9438-0_19

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  • DOI: https://doi.org/10.1007/978-1-4939-9438-0_19

  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-9437-3

  • Online ISBN: 978-1-4939-9438-0

  • eBook Packages: Springer Protocols

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