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Chiral Separations pp 339–356Cite as

Cyclodextrins as Chiral Selectors in Capillary Electrophoresis Enantioseparations

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1985))

Abstract

Due to their structural variability and their commercial availability, cyclodextrins are the most frequently used chiral selectors in capillary electrophoresis. A variety of migration modes can be realized depending on the characteristics of the cyclodextrins and the analytes. The basic considerations regarding the development of a chiral CE method employing cyclodextrins as chiral selectors are briefly discussed. The presented examples illustrate the separation modes of an acidic and a basic analyte with native and charged cyclodextrin derivatives as a function of the pH of the background electrolyte and the concentration of the cyclodextrin.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, University of Jena, Jena, Germany

    Gerhard K. E. Scriba

  2. Faculty of Pharmacy in Hradec Králové, Department of Analytical Chemistry, Charles University, Hradec Králové, Czech Republic

    Pavel Jáč

Authors
  1. Gerhard K. E. Scriba
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  2. Pavel Jáč
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Correspondence to Pavel Jáč .

Editor information

Editors and Affiliations

  1. Department of Pharmaceutical Chemistry, University of Jena, Jena, Germany

    Gerhard K. E. Scriba

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Scriba, G.K.E., Jáč, P. (2019). Cyclodextrins as Chiral Selectors in Capillary Electrophoresis Enantioseparations. In: Scriba, G.K.E. (eds) Chiral Separations. Methods in Molecular Biology, vol 1985. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9438-0_18

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  • DOI: https://doi.org/10.1007/978-1-4939-9438-0_18

  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-9437-3

  • Online ISBN: 978-1-4939-9438-0

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