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Chiral Separations by Countercurrent Chromatography

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Book cover Chiral Separations

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1985))

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Abstract

Chiral separations by countercurrent chromatography are mainly divided into two types: homogeneous chiral selector addition and interfacial chiral ligand exchange. In this chapter, we describe two methods for the enantioseparation of phenylsuccinic acid and α-hydroxy acids by high-speed countercurrent chromatography using hydroxypropyl-β-cyclodextrin and N-n-dodecyl-l-proline as chiral selectors for both above mentioned modes.

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Acknowledgments

The financial support by the National Natural Science Foundation (No. 21105090), Zhejiang Province Natural Science Foundation (No. Y4100472), and Zhaohui Program of Zhejiang University of Technology (2013) is gratefully acknowledged.

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Authors and Affiliations

  1. College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, People’s Republic of China

    Sheng-Qiang Tong

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  1. Sheng-Qiang Tong
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Correspondence to Sheng-Qiang Tong .

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Editors and Affiliations

  1. Department of Pharmaceutical Chemistry, University of Jena, Jena, Germany

    Gerhard K. E. Scriba

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Tong, SQ. (2019). Chiral Separations by Countercurrent Chromatography. In: Scriba, G.K.E. (eds) Chiral Separations. Methods in Molecular Biology, vol 1985. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9438-0_17

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  • DOI: https://doi.org/10.1007/978-1-4939-9438-0_17

  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-9437-3

  • Online ISBN: 978-1-4939-9438-0

  • eBook Packages: Springer Protocols

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