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Design of Eco-Friendly Gold Nanoparticles for Cancer Treatment

  • Deep Pooja
  • Ramakrishna Sistla
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1974)

Abstract

Gold nanoparticles (GNPs) have emerged as a potential scaffold for a wide range of biomedical applications such as biosensing, drug delivery, and imaging. However, the toxicity of nanoparticles remains a challenge for using them in biological system. The morphology and surface chemistry of GNP can be manipulated by their method of preparation. GNP can be synthesized and functionalized by various methods. This chapter illustrates the synthesis of highly biocompatible GNP using a natural gum, i.e., xanthan gum (XG). Moreover, due to the presence of mannose moiety in XG, these XG-stabilized GNP may also act as self-targeted drug carriers for the delivery of chemotherapeutic agents/siRNA/shRNA to mannose receptor overexpressing cancer cells.

Keywords

Xanthan gum Gold nanoparticles Biocompatibility Chemotherapy Drug delivery 

Notes

Acknowledgments

The work described in this book chapter has been published as Deep Pooja et al., Xanthan gum stabilized gold nanoparticles: Characterization, biocompatibility, stability and cytotoxicity. Carbohydrate Polymers 2014;110:1–9. The work is reused after permission from Elsevier under license number 4236430677285.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Deep Pooja
    • 1
  • Ramakrishna Sistla
    • 1
  1. 1.Pharmacology and Toxicology DivisionCSIR-Indian Institute of Chemical TechnologyHyderabadIndia

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