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Non-Natural Nucleic Acids pp 91–106Cite as

Synthesis Protocols for Simple Uncharged Glycol Carbamate Nucleic Acids

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1973))

Abstract

Glycol carbamate nucleic acid (GCNA) oligomers can be produced from activated carbonate monomers. The synthesized monomers can be very conveniently characterized employing analytical tools like NMR and HR-MS. Moreover, the activated carbonate monomers do not require coupling agents, and hence excess monomers can be recovered at the end of each coupling. Here we illustrate the synthesis of activated glycol carbonate monomers and their subsequent application in synthesis of carbamate oligomers.

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Acknowledgments

T.B. acknowledges Senior Research Fellowship from CSIR, New Delhi. V.A.K. acknowledges financial support from CSIR, New Delhi (BSC0123).

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Authors and Affiliations

  1. CSIR-National Chemical Laboratory, Pune, Maharashtra, India

    Tanaya Bose

  2. CSIR-National Chemical Laboratory, Organic Chemistry Division, Pune, Maharashtra, India

    Vaijayanti A. Kumar

Authors
  1. Tanaya Bose
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  2. Vaijayanti A. Kumar
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Corresponding author

Correspondence to Vaijayanti A. Kumar .

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Editors and Affiliations

  1. Department of Chemistry and Biochemistry, Georgia Southern University, Savannah, GA, USA

    Nathaniel Shank

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Bose, T., Kumar, V.A. (2019). Synthesis Protocols for Simple Uncharged Glycol Carbamate Nucleic Acids. In: Shank, N. (eds) Non-Natural Nucleic Acids. Methods in Molecular Biology, vol 1973. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9216-4_6

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  • DOI: https://doi.org/10.1007/978-1-4939-9216-4_6

  • Published:

  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-9215-7

  • Online ISBN: 978-1-4939-9216-4

  • eBook Packages: Springer Protocols

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