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Origin and Pathogenesis of B Cell Lymphomas

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Lymphoma

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1956))

Abstract

Immunoglobulin (IG) gene remodeling by V(D)J recombination plays a central role in the generation of normal B cells, and somatic hypermutation and class switching of IG genes are key processes during antigen-driven B cell differentiation. However, errors of these processes are involved in the development of B cell lymphomas. IG locus-associated translocations of proto-oncogenes are a hallmark of many B cell malignancies. Additional transforming events include inactivating mutations in various tumor suppressor genes and also latent infection of B cells with viruses, such as Epstein-Barr virus. Many B cell lymphomas require B cell antigen receptor expression, and in several instances, chronic antigenic stimulation plays a role in lymphoma development and/or sustaining tumor growth. Often, survival and proliferation signals provided by other cells in the microenvironment are a further critical factor in lymphoma development and pathophysiology. Many B cell malignancies derive from germinal center B cells, most likely because of the high proliferation rate of these cells and the high activity of mutagenic processes.

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Acknowledgments

Own work discussed in this review was supported by grants from the Deutsche Forschungsgemeinschaft (KU1315/8-1, KU1315/9-2, KU1315/10-1, TRR60), the Deutsche Krebshilfe, the Wilhelm Sander Foundation, the Hairy Cell Leukemia Foundation, the SASS Foundation for Medical research, and the Werner Jackstädt-Stiftung. We thank the other members of our group and Martin-Leo Hansmann for many stimulating discussions.

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    Marc Seifert, René Scholtysik & Ralf Küppers

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Seifert, M., Scholtysik, R., Küppers, R. (2019). Origin and Pathogenesis of B Cell Lymphomas. In: Küppers, R. (eds) Lymphoma. Methods in Molecular Biology, vol 1956. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-9151-8_1

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