Abstract
The use of viral vector-mediated α-synuclein-overexpressing rodent models for Parkinson’s disease has become increasingly accepted to study associated pathology and to use as a platform for therapeutic efficacy testing. We here describe methods to generate such models and how to analyze them by behavioral assessments, histological investigations, and examination of nigrostriatal dopaminergic function.
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References
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Acknowledgments
This project was supported by the Interdisciplinary Center for Clinical Research (IZKF) at the University of Würzburg (A-303).
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Karikari, A.A., Koprich, J.B., Ip, C.W. (2019). Generation and Analysis of Viral Vector-Mediated Rodent Models for Parkinson’s Disease. In: Bartels, T. (eds) Alpha-Synuclein. Methods in Molecular Biology, vol 1948. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-9124-2_21
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DOI: https://doi.org/10.1007/978-1-4939-9124-2_21
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Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-9123-5
Online ISBN: 978-1-4939-9124-2
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