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Fragile-X Syndrome pp 141–153Cite as

Application of Drosophila Model Toward Understanding the Molecular Basis of Fragile X Syndrome

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1942))

Abstract

Drosophila melanogaster is an ideal model to study Fragile X syndrome (FXS) as it presents us with a toolbox to identify genetic modifiers and to investigate the molecular mechanisms of FXS. Here we describe some of the methods that have been used to study FXS, ranging from reverse genetic screening using the GAL4-UAS system, to mushroom body staining and courtship behavioral assays to examine the learning and memory deficits associated with FXS.

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Author information

Authors and Affiliations

  1. Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA

    Ha Eun Kong, Junghwa Lim & Peng Jin

Authors
  1. Ha Eun Kong
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  2. Junghwa Lim
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  3. Peng Jin
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Corresponding author

Correspondence to Peng Jin .

Editor information

Editors and Affiliations

  1. Wolfe PGD Stem Cell Lab, Racine IVF Unit at Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel

    Dalit Ben-Yosef

  2. Wolfe PGD Stem Cell Lab, Racine IVF Unit at Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel

    Yoav Mayshar

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Kong, H.E., Lim, J., Jin, P. (2019). Application of Drosophila Model Toward Understanding the Molecular Basis of Fragile X Syndrome. In: Ben-Yosef, D., Mayshar, Y. (eds) Fragile-X Syndrome. Methods in Molecular Biology, vol 1942. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-9080-1_12

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  • DOI: https://doi.org/10.1007/978-1-4939-9080-1_12

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-9079-5

  • Online ISBN: 978-1-4939-9080-1

  • eBook Packages: Springer Protocols

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