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Current Use of Adenovirus Vectors and Their Production Methods

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Viral Vectors for Gene Therapy

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1937))

Abstract

Various adenovirus (AdV) vector systems have proven to be lucrative options for gene delivery. They can serve as potential vaccine candidates for prevention of several common infectious diseases and hold the promise for gene therapy, especially for cancer. Several AdV vector-based therapies are currently at various stages of clinical trials worldwide, which make an immense interest of both the clinicians and researchers. Since these vectors are easy to manipulate, have broad tropism, and have the capability to yield high titers, this delivery system has a wide range of applications for different clinical settings. This chapter emphasizes on some of the current usages of AdV vectors and their production methods.

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Acknowledgments

This work was supported by the Public Health Service grant—AI059374 from the National Institute of Allergy and Infectious Diseases, and the Hatch and Animal Health funds.

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Authors and Affiliations

  1. Department of Comparative Pathobiology, Purdue Institute for Inflammation, Immunology, and Infectious Disease, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA

    Ekramy E. Sayedahmed, Rashmi Kumari & Suresh K. Mittal

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  1. Ekramy E. Sayedahmed
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  3. Suresh K. Mittal
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Correspondence to Suresh K. Mittal .

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  1. Translational Science and Molecular Medicine, Michigan State University, Grand Rapids, MI, USA

    Fredric P. Manfredsson

  2. Translational Science and Molecular Medicine, Michigan State University, Grand Rapids, MI, USA

    Matthew J. Benskey

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Sayedahmed, E.E., Kumari, R., Mittal, S.K. (2019). Current Use of Adenovirus Vectors and Their Production Methods. In: Manfredsson, F., Benskey, M. (eds) Viral Vectors for Gene Therapy. Methods in Molecular Biology, vol 1937. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-9065-8_9

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