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Multiwalled Carbon Nanotubes for Dental Applications

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Odontogenesis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1922))

Abstract

Multiwalled carbon nanotubes (MWCNTs) are a particularly promising drug delivery system due to their high surface area allowing high-protein loading, their stability under biological conditions, and their unique interaction with cellular membranes. Studies have shown that covalent attachment of polyethylene glycol (PEG) improves biocompatibility and enhances surface hydrophilicity properties, suggesting that PEGylated MWCNTs are efficient and toxic-safe drug delivery systems. So far, CNTs are used for a broad range of applications in dentistry, especially for dental tissue repair and restorative. Here we present a protocol of protein immobilization onto MWCNTs and describe the procedure for delivering them into the cells after characterization of the nanotubes.

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Acknowledgments

We would like to acknowledge the University of Saskatchewan College of Medicine CoMGRAD postdoctoral fellowship awarded to Petros Kechagioglou.

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Authors and Affiliations

  1. Department of Surgery, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada

    Petros Kechagioglou & Silvana Papagerakis

  2. College of Dentistry, University of Saskatchewan, Saskatoon, SK, Canada

    Petros Kechagioglou & Petros Papagerakis

  3. Laboratory of Organic Chemical Technology, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece

    Eleftherios Andriotis

  4. School of Dentistry, University of Michigan, Ann Arbor, MI, USA

    Petros Papagerakis

  5. Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada

    Silvana Papagerakis

  6. Toxicology Interdisciplinary Program, University of Saskatchewan, Saskatoon, SK, Canada

    Silvana Papagerakis

  7. College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada

    Silvana Papagerakis

  8. Department of Otolaryngology - Head and Neck Surgery, Medical School, University of Michigan, Ann Arbor, MI, USA

    Silvana Papagerakis

Authors
  1. Petros Kechagioglou
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  2. Eleftherios Andriotis
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  3. Petros Papagerakis
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  4. Silvana Papagerakis
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Corresponding author

Correspondence to Petros Kechagioglou .

Editor information

Editors and Affiliations

  1. School of Dentistry, University of Michigan, Ann Arbor, MI, USA

    Petros Papagerakis

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Kechagioglou, P., Andriotis, E., Papagerakis, P., Papagerakis, S. (2019). Multiwalled Carbon Nanotubes for Dental Applications. In: Papagerakis, P. (eds) Odontogenesis. Methods in Molecular Biology, vol 1922. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-9012-2_12

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  • DOI: https://doi.org/10.1007/978-1-4939-9012-2_12

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-9011-5

  • Online ISBN: 978-1-4939-9012-2

  • eBook Packages: Springer Protocols

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