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Computational Biology of Non-Coding RNA pp 427–445Cite as

Modeling Long ncRNA-Mediated Regulation in the Mammalian Cell Cycle

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1912))

Abstract

Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides that are not translated into proteins. They have recently gained widespread attention due to the finding that tens of thousands of lncRNAs reside in the human genome, and due to an increasing number of lncRNAs that are found to be associated with disease. Some lncRNAs, including disease-associated ones, play different roles in regulating the cell cycle. Mathematical models of the cell cycle have been useful in better understanding this biological system, such as how it could be robust to some perturbations and how the cell cycle checkpoints could act as a switch. Here, we discuss mathematical modeling techniques for studying lncRNA regulation of the mammalian cell cycle. We present examples on how modeling via network analysis and differential equations can provide novel predictions toward understanding cell cycle regulation in response to perturbations such as DNA damage.

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Acknowledgments

This work is dedicated to the memory of Dr. Baltazar D. Aguda. JFR is supported by the PCARI-CHED IHITM 2017-018 project: Glycoproteomics of Filipino lung cancer cell lines for biomarker discovery and anti-cancer screening of natural products.

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Authors and Affiliations

  1. Institute of Mathematical Sciences and Physics, University of the Philippines Los Baños, Laguna, Philippines

    Jomar F. Rabajante

  2. Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA

    Ricardo C. H. del Rosario

Authors
  1. Jomar F. Rabajante
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  2. Ricardo C. H. del Rosario
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Correspondence to Jomar F. Rabajante .

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Editors and Affiliations

  1. Department of Dermatology, Erlangen University Hospital, Erlangen, Germany

    Xin Lai

  2. Department of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany

    Shailendra K. Gupta

  3. Department of Dermatology, Erlangen University Hospital, Erlangen, Germany

    Julio Vera

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Rabajante, J.F., del Rosario, R.C.H. (2019). Modeling Long ncRNA-Mediated Regulation in the Mammalian Cell Cycle. In: Lai, X., Gupta, S., Vera, J. (eds) Computational Biology of Non-Coding RNA. Methods in Molecular Biology, vol 1912. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8982-9_17

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  • DOI: https://doi.org/10.1007/978-1-4939-8982-9_17

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8981-2

  • Online ISBN: 978-1-4939-8982-9

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