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Mouse Models for Studying HCV Vaccines and Therapeutic Antibodies

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Hepatitis C Virus Protocols

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1911))

Abstract

In spite of the immense progress in hepatitis C virus (HCV) research, efforts to prevent infection, such as generating a vaccine, have not yet been successful. The high price tag associated with current treatment options for chronic infection and the spike in new infections concurrent with growing opioid abuse are strong motivators for developing effective immunization and understanding neutralizing antibodies’ role in preventing infection. Humanized mice—both human liver chimeras as well as genetically humanized models—are important platforms for testing both possible vaccine candidates as well as antibody-based therapies. This chapter details the variety of ways humanized mouse technology can be employed in pursuit of learning how HCV infection can be prevented.

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Acknowledgments

This study is supported by grants from the National Institutes of Health (R01 AI079031, R01 AI107301, R21AI117213 to A.P.), a Research Scholar Award from the American Cancer Society (RSG-15-048-01-MPC to A.P.), a Burroughs Wellcome Fund Award for Investigators in Pathogenesis (to A.P.) and funds from Princeton University. J.M.G. was in part supported by cofunding from NIAID on iNRSA 5T32GM00738 and Q.D. by a postdoctoral fellowship from the New Jersey Commission on Cancer Research.

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Authors and Affiliations

  1. Lewis Thomas Laboratory, Department of Molecular Biology, Princeton University, Princeton, NJ, USA

    Jenna M. Gaska, Qiang Ding & Alexander Ploss

  2. School of Medicine, Tsinghua University, Beijing, China

    Qiang Ding

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  1. Jenna M. Gaska
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  2. Qiang Ding
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  3. Alexander Ploss
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Correspondence to Alexander Ploss .

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Editors and Affiliations

  1. Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA

    Mansun Law

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Gaska, J.M., Ding, Q., Ploss, A. (2019). Mouse Models for Studying HCV Vaccines and Therapeutic Antibodies. In: Law, M. (eds) Hepatitis C Virus Protocols . Methods in Molecular Biology, vol 1911. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8976-8_33

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  • DOI: https://doi.org/10.1007/978-1-4939-8976-8_33

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