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Cell-free DNA as Diagnostic Markers pp 129–135Cite as

Epigenetic Characterization of Cell-Free DNA

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1909))

Abstract

Cell-free DNA can be evaluated for the epigenetic component. Epigenetic alterations consist of changes in gene functions that do not involve changes in DNA sequence. The mainly studied epigenetic alteration is DNA methylation occurring at CpG islands in the promoter regions for which several literature data showed clinical relevance. This chapter is an overview of the epigenetic alterations detected in cell-free DNA.

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Authors and Affiliations

  1. Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

    Giorgia Gurioli

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  1. Giorgia Gurioli
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Correspondence to Giorgia Gurioli .

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Editors and Affiliations

  1. Biosciences Laboratory, IRCCS I.R.S.T, Meldola, Italy

    Valentina Casadio

  2. Biosciences Laboratory, IRCCS I.R.S.T, Meldola, Italy

    Samanta Salvi

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Gurioli, G. (2019). Epigenetic Characterization of Cell-Free DNA. In: Casadio, V., Salvi, S. (eds) Cell-free DNA as Diagnostic Markers. Methods in Molecular Biology, vol 1909. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8973-7_10

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  • DOI: https://doi.org/10.1007/978-1-4939-8973-7_10

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8972-0

  • Online ISBN: 978-1-4939-8973-7

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