Abstract
The protocol below describes an in silico method for drug repositioning (drug repurposing). The data source is ClinicalTrials.gov, which contains about a quarter of a million clinical studies. Mining such rich and clean clinical summary data could be helpful to many health-related researches. Described here is a method that utilizes serious adverse event data to identify potential new uses of drugs and dietary supplements (repositioning).
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References
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Acknowledgments
This work was supported by Eli Lilly and Company.
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: Drug Repositioning by Mining Adverse Event Data in ClinicalTrials.gov (DOCX 17Â kb)
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Su, E.W. (2019). Drug Repositioning by Mining Adverse Event Data in ClinicalTrials.gov. In: Vanhaelen, Q. (eds) Computational Methods for Drug Repurposing. Methods in Molecular Biology, vol 1903. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8955-3_4
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DOI: https://doi.org/10.1007/978-1-4939-8955-3_4
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Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-8954-6
Online ISBN: 978-1-4939-8955-3
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