Immune Tolerance and Rejection in Organ Transplantation

  • Jessica Stolp
  • Masaaki Zaitsu
  • Kathryn J. WoodEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 1899)


In this chapter, we describe the history of transplantation, the multiple cell types, and mechanisms that are involved in rejection and tolerance of a transplanted organ, as well as summarize the common and promising new therapeutics used in transplant patients.

Key words

Organ transplant Transplant tolerance Immune mechanisms of rejection T cells B cells Regulatory cells Clinical symptoms of rejection Immunosuppression Cell therapy 



The work from the authors’ own laboratory described in this review was supported by grants from The Wellcome Trust, Medical Research council, BBSRC, British Heart Foundation, and European Union through the ONE Study, Bio-DrIM and TRIAD projects. The authors would like to thank all members of TRIG past and present for their valuable contributions to the data reviewed herein. The authors have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Jessica Stolp
    • 1
  • Masaaki Zaitsu
    • 1
  • Kathryn J. Wood
    • 1
    Email author
  1. 1.Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, John Radcliffe HospitalUniversity of OxfordOxfordUK

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