Abstract
Cerebrospinal fluid (CSF) is a physiologically essential fluid produced by the brain that is involved in protecting the brain and in the exchange of nutrients and waste products. CSF has long been utilized to confirm clinical suspicion of various infectious and inflammatory disorders, such as meningitis and multiple sclerosis. However, there has been increasing interest in collecting CSF in order to study the clinical significance of additional biomarkers. This chapter outlines the procedures necessary to collect, process, store, and utilize CSF obtained for the purposes of biobanking from both living and deceased patients.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Ma MJ, Perry A, Brat DJ (2010) Biopsy pathology of neurodegenerative disorders in adults. In: Practical surgical neuropathology: a diagnostic approach. Churchill Livingstone/Elsevier, Philadelphia, pp 566–570
Ellison D, Love S, Chimelli L et al (2013) Prion diseases. In: Neuropathology: a reference text of CNS pathology, 3rd edn. Mosby/Elsevier, Maryland Heights, p 676
Willemse EA, Teunissen CE (2015) Biobanking of cerebrospinal fluid for biomarker analysis in neurological diseases. In: Karimi-Busheri F (ed) Biobanking in the 21st century. Springer International Publishing, Switzerland, pp 79–93
Brat DJ (2010) Normal brain histopathology. In: Perry A, Brat DJ (eds) Practical surgical neuropathology: a diagnostic approach. Churchill Livingstone/Elsevier, Philadelphia, p 20
Martino G, Grimaldi LM, Moiola L et al (1990) Discontinuous distribution of IgG oligoclonal bands in cerebrospinal fluid from multiple sclerosis patients. J Neuroimmunol 30(2–3):129–134
Teunissen CE, Tumani H, Bennett JL et al (2011) Consensus guidelines for CSF and blood biobanking for CNS biomarker studies. Mult Scler Int 2011:246412
Liu A, Pollard K (2015) Biobanking for personalized medicine. In: Karimi-Busheri F (ed) Biobanking in the 21st century. Springer International Publishing, Switzerland, pp 55–68
Wong FWH (2011) Cerebrospinal fluid collection: a comparison of different collection sites on the external ventricular drain. Dynamics 22:19–24
Peskind ER, Riekse R, Quinn JF et al (2005) Safety and acceptability of the research lumbar puncture. Alzheimer Dis Assoc Disord 19(4):220–225
Carson D, Serpell M (1996) Choosing the best needle for diagnostic lumbar puncture. Neurology 47(1):33–37
Lewczuk P, Beck G, Esselmann H et al (2006) Effect of sample collection tubes on cerebrospinal fluid concentrations of tau proteins and amyloid beta peptides. Clin Chem 52(2):332–334
Murillo-Rodriguez E, Désarnaud F, Prospéro-GarcÃa O (2006) Diurnal variation of arachidonoylethanolamide, palmitoylethanolamide and oleoylethanolamide in the brain of the rat. Life Sci 79(1):30–37
Grant R, Condon B, Hart I, Teasdale GM (1991) Changes in intracranial CSF volume after lumbar puncture and their relationship to post-LP headache. J Neurol Neurosurg Psychiatry 54(5):440–442
Kuntz KM, Kokmen E, Stevens JC et al (1992) Post-lumbar puncture headaches: experience in 501 consecutive procedures. Neurology 42(10):1884–1887
Acknowledgments
This work was supported in part by NIH:NCI P50-CA211015, NIH:NIMH U24 MH100929, the Art of the Brain Foundation, and the Henry E. Singleton Brain Cancer Research Program.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Science+Business Media, LLC, part of Springer Nature
About this protocol
Cite this protocol
Tashjian, R.S., Vinters, H.V., Yong, W.H. (2019). Biobanking of Cerebrospinal Fluid. In: Yong, W. (eds) Biobanking. Methods in Molecular Biology, vol 1897. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8935-5_11
Download citation
DOI: https://doi.org/10.1007/978-1-4939-8935-5_11
Published:
Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-8933-1
Online ISBN: 978-1-4939-8935-5
eBook Packages: Springer Protocols