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Computational Methods for Analysis of Tumor Clonality and Evolutionary History

  • Gerald Goh
  • Nicholas McGranahan
  • Gareth A. Wilson
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1878)

Abstract

Cancer is an evolutionary process. Recent advances in sequencing technologies have allowed us to investigate intratumor heterogeneity at the single nucleotide level. Here, we describe computational methods that use sequencing data to identify genetically distinct tumor subclones and reconstruct tumor evolutionary histories.

Key words

Cancer Next-generation sequencing Heterogeneity Clonal Evolution Phylogeny 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Gerald Goh
    • 1
    • 2
  • Nicholas McGranahan
    • 1
  • Gareth A. Wilson
    • 3
    • 4
  1. 1.Cancer Research UK Lung Cancer Centre of ExcellenceUniversity College London Cancer InstituteLondonUK
  2. 2.Genome Institute of SingaporeSingaporeSingapore
  3. 3.Cancer Research UK Lung Cancer Centre of ExcellenceUniversity College London Cancer InstituteLondonUK
  4. 4.Translational Cancer Therapeutics LaboratoryThe Francis Crick InstituteLondonUK

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