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Brain Tumor Stem Cells pp 1–9Cite as

Introduction to Brain Tumor Stem Cells

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1869))

Abstract

From stem cells, to the cancer stem cell hypothesis and intratumoral heterogeneity, the following introductory chapter on brain tumor stem cells explores the history of normal and cancerous stem cells, and their implication in the current model of brain tumor development. The origins of stem cells date back to the 1960s, when they were first described as cells capable of self-renewal, extensive proliferation, and differentiation. Since then, many advances have been made and adult stem cells are now known to be present in a very wide variety of tissues. Neural stem cells were subsequently discovered 30 years later, which was shortly followed by the discovery of cancer stem cells in leukemia and in brain tumors over the next decade, effectively enabling a new understanding of cancer. Since then, many markers including CD133, brain cancer stem cells have been implicated in a variety of phenomena including intratumoral heterogeneity on the genomic, cellular, and functional levels, tumor initiation, chemotherapy-resistance, radiation-resistance, and are believed to be ultimately responsible for tumor relapse. Understanding this small and rare population of cells could be the key to solving the great enigma that is cancer.

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Author information

Authors and Affiliations

  1. McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, Canada

    Nicolas Yelle & David Bakhshinyan

  2. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada

    Nicolas Yelle, David Bakhshinyan & Sheila K. Singh

  3. Department of Surgery, McMaster University, Hamilton, ON, Canada

    Sheila K. Singh

  4. Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, Canada

    Chitra Venugopal & Sheila K. Singh

  5. Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada

    Chitra Venugopal

Authors
  1. Nicolas Yelle
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  2. David Bakhshinyan
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  3. Chitra Venugopal
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  4. Sheila K. Singh
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Corresponding author

Correspondence to Sheila K. Singh .

Editor information

Editors and Affiliations

  1. Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, Canada

    Sheila K. Singh

  2. Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, Canada

    Chitra Venugopal

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Yelle, N., Bakhshinyan, D., Venugopal, C., Singh, S.K. (2019). Introduction to Brain Tumor Stem Cells. In: Singh, S., Venugopal, C. (eds) Brain Tumor Stem Cells. Methods in Molecular Biology, vol 1869. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8805-1_1

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  • DOI: https://doi.org/10.1007/978-1-4939-8805-1_1

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8804-4

  • Online ISBN: 978-1-4939-8805-1

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