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Tertiary Lymphoid Structures Among the World of Noncanonical Ectopic Lymphoid Organizations

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Tertiary Lymphoid Structures

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1845))

Abstract

Tertiary lymphoid structures (TLOs), also known as ectopic lymphoid structures, are associated with chronic infections and inflammatory diseases. Despite their association with pathology, these structures are actually a normal, albeit transient, component of the immune system and facilitate local immune responses that are meant to mitigate inflammation and resolve infection. Many of the mechanisms controlling the formation and function of tertiary lymphoid structures have been identified, in part by experimentally triggering their formation using defined stimuli under controlled conditions. Here, we introduce the experimental and pathological conditions in which tertiary lymphoid tissues are formed, describe the mechanisms linked to their formation, and discuss their functions in the context of both infection and inflammation.

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Authors and Affiliations

  1. Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA

    Aaron Silva-Sanchez, Troy D. Randall & Selene Meza-Perez

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  1. Aaron Silva-Sanchez
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  2. Troy D. Randall
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  3. Selene Meza-Perez
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Correspondence to Troy D. Randall .

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  1. Laboratory “Cancer, Immune Control and Escape”, UMRS 1138 INSERM, Cordeliers Research Center, Sorbonne University, UMR 1138, Paris Descartes University, Sorbonne Paris City, UMR 1138, Paris, France

    Marie-Caroline Dieu-Nosjean

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Silva-Sanchez, A., Randall, T.D., Meza-Perez, S. (2018). Tertiary Lymphoid Structures Among the World of Noncanonical Ectopic Lymphoid Organizations. In: Dieu-Nosjean, MC. (eds) Tertiary Lymphoid Structures. Methods in Molecular Biology, vol 1845. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8709-2_1

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