Abstract
A biosensor is a device composed by a biological recognition element and a transducer that delivers selective information about a specific analyte. Technological and scientific advances in the area of biology, bioengineering, catalysts, electrochemistry, nanomaterials, microelectronics, and microfluidics have improved the design and performance of better biosensors. Enzymatic biosensors based on lipases, esterases, and phospholipases are valuable analytical apparatus which have been applied in food industry, oleochemical industry, biodegradable polymers, environmental science, and overall the medical area as diagnostic tools to detect cholesterol and triglyceride levels in blood samples. This chapter reviews recent developments and applications of lipase-, esterase-, and phospholipase-based biosensors.
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References
Clark LC, Lyons C (1962) Electrode systems for continuous monitoring in cardiovascular surgery. Ann N Y Acad Sci 102:29–45
Mohanty SP (2006) Biosensors: a tutorial review. IEEE Potentials 25:35–40
Mehrotra P (2016) Biosensors and their applications – a review. J Oral Biol Craniofacial Res 6:153–159
Biechele P, Busse C, Solle D et al (2015) Sensor systems for bioprocess monitoring. Eng Life Sci 15:469–488
Ferreira LS, De Souza MB, Trierweiler JO et al (2003) Aspects concerning the use of biosensors for process control: experimental and simulation investigations. Comput Chem Eng 27:1165–1173
Farina D, Zinellu M, Fanari M et al (2017) Development of a biosensor telemetry system for monitoring fermentation in craft breweries. Food Chem 218:479–486
Durrieu C, Tran-Minh C (2002) Optical algal biosensor using alkaline phosphatase for determination of heavy metals. Ecotoxicol Environ Saf 51:206–209
Durrieu C, Chouteau C, Barthet L et al (2004) A bi-enzymatic whole-cell algal biosensor for monitoring waste water pollutants. Anal Lett 37:1589–1599
Tan L, Schirmer K (2017) Cell culture-based biosensing techniques for detecting toxicity in water. Curr Opin Biotechnol 45:59–68
Rogers K (1995) Biosensors for environmental applications. Biosens Bioelectron 10:533–541
Jaffrezic-Renault N (2001) New trends in biosensors for organophosphorus pesticides. Sensors 1:60–74
Rodriguez-Mozaz S, Maria-Pilar M, Lopez de Alda M, Barceló D (2004) Biosensors for environmental applications: Future development trends. Pure Appl Chem 76:723–752
Amine A, Mohammadi H, Bourais I, Palleschi G (2006) Enzyme inhibition-based biosensors for food safety and environmental monitoring. Biosens Bioelectron 21:1405–1423
Serna C, Zetty A, Ayala A (2009) Use of enzymatic biosensors as quality indices: a synopsis of present and future trends in the food industry. Chil J Agric Res 69:270–280
Pérez-López B, Merkoçi A (2011) Nanomaterials based biosensors for food analysis applications. Trends Food Sci Technol 22:625–639
Ivnitski D, Abdel-Hamid I, Atanasov P, Wilkins E (1999) Biosensors for detection of pathogenic bacteria. Biosens Bioelectron 14:599–624
Poltronieri P, Mezzolla V, Primiceri E, Maruccio G (2014) Biosensors for the detection of food pathogens. Foods 3:511–526
Tegos GP (2013) Biodefense: trends and challenges in combating biological warfare agents. Virulence 4:740–744
Fei J, Wu Y, Ji X et al (2003) An amperometric biosensor for glucose based on electrodeposited redox polymer/glucose oxidase film on a gold electrode. Anal Sci 19:1259–1263
Pizzariello A, Stredanský M, Stredanská S, Miertuš S (2001) Urea biosensor based on amperometric pH-sensing with hematein as a pH-sensitive redox mediator. Talanta 54:763–772
Je-Kyun P, Hee-Jin Y, Kang S et al (1999) Determination of breath alcohol using a differential-type amperometric biosensor based on alcohol dehydrogenase. Anal Chim Acta 390:83–91
Murugaiyan SB, Ramasamy R, Gopal N, Kuzhandaivelu V (2014) Biosensors in clinical chemistry: an overview. Adv Biomed Res 3:67
Singh R, Mukherjee M, Sumana G et al (2014) Biosensors for pathogen detection: a smart approach towards clinical diagnosis. Sensors Actuators B Chem 197:385–404
Wang J (2006) Electrochemical biosensors: towards point-of-care cancer diagnostics. Biosens Bioelectron 21:1887–1892
He Q, Lei H, Luo S et al (2017) Liquid crystal biosensor for detecting ischemia modified albumin. Res Chem Intermed 43:353–360
Castillo J, Gáspár S, Leth S et al (2004) Biosensors for life quality- design, development and applications. Sensors Actuat B Chem 102:179–194
Luong JHT, Male KB, Glennon JD (2008) Biosensor technology: technology push versus market pull. Biotechnol Adv 26:492–500
Lopes DB, Fraga LP, Fleuri LF, Macedo GA (2011) Lipase and esterase: to what extent can this classification be applied accurately? Ciência e Tecnol Aliment 31:603–613
Ali Y, Verger R, Abousalham A (2012) Lipases or esterases: does it really matter? Toward a new bio-physico-chemical classification. In: Sandoval G (ed) Lipases phospholipases methods protocols. Humana Press, Totowa, NJ, pp 31–51
Jaeger KE, Eggert T (2002) Lipases for biotechnology. Curr Opin Biotechnol 13:390–397
Panda T, Gowrishankar BS (2005) Production and applications of esterases. Appl Microbiol Biotechnol 67:160–169
De Maria L, Vind J, Oxenbøll KM et al (2007) Phospholipases and their industrial applications. Appl Microbiol Biotechnol 74:290–300
Hasan F, Shah AA, Hameed A (2006) Industrial applications of microbial lipases. Enzym Microb Technol 39:235–251
Market_Reports (2017) Biosensors market by application (POC, home diagnostics, research labs, biodefense, environmental monitoring, Food & Beverages Industry), technology, product (wearable and non-wearable), and geography – global forecast to 2022. In: Markets&Markets. http://www.marketsandmarkets.com/Market-Reports/biosensors-market-798.html. Accessed 1 Oct 2017
Thévenot DR, Toth K, Durst RA, Wilson GS (2001) Electrochemical biosensors: recommended definitions and classification. Biosens Bioelectron 16:121–131
Velasco-Garcia MN, Mottram T (2003) Biosensor technology addressing agricultural problems. Biosyst Eng 84:1–12
Ramanathan K, Danielsson B (2001) Principles and applications of thermal biosensors. Biosens Bioelectron 16:417–423
Marazuela MD, Moreno-Bondi MC (2002) Fiber-optic biosensors – an overview. Anal Bioanal Chem 372:664–682
Notingher I (2007) Raman spectroscopy cell-based biosensors. Sensors 7:1343–1358
Singh P (2016) SPR biosensors: historical perspectives and current challenges. Sensors Actuators B Chem 229:110–130
Vigneshvar S, Sudhakumari CC, Senthilkumaran B, Prakash H (2016) Recent advances in biosensor technology for potential applications – an overview. Front Bioeng Biotechnol 4:1–9
Vo-Dinh T, Cullum B (2008) Biosensors and biochips: advances in biological and medical diagnostics. Fresenius J Anal Chem 366:540–551
Länge K, Rapp BE, Rapp M (2008) Surface acoustic wave biosensors: a review. Anal Bioanal Chem 391:1509–1519
Pohanka M (2017) The piezoelectric biosensors: principles and applications, a review. Int J Electrochem Sci 12:496–506
Alloush HM, Lewis RJ, Salisbury VC (2006) Bacterial bioluminescent biosensors: applications in food and environmental monitoring. Anal Lett 39:1517–1526
Yogeswaran U, Shen-Ming C (2008) A review on the electrochemical sensors and biosensors composed of nanowires as sensing material. Sensors 8:290–313
Pohanka M, Skládal P (2008) Electrochemical biosensors – principles and applications. Methods 6:57–64
Dzyadevych SV, Arkhypova VN, Soldatkin AP et al (2008) Amperometric enzyme biosensors: past, present and future. IRBM 29:171–180
Pisoschi AM (2016) Potentiometric biosensors: concept and analytical applications-an editorial. Biochem Anal Biochem 5:19–20
Buck RP, Lindner E (1994) Recommendations for nomenclature of ionselective electrodes. Pure Appl Chem 66:2527–2536
Khanna VK (2007) Advances in chemical sensors, biosensors and microsystems based on ion-sensitive field-effect transistor. Ind J Pure Appl Phys 45:345–353
Mehrvar M, Abdi M (2004) Recent developments, characteristics, and potential applications of electrochemical biosensors. Anal Sci 20:1113–1126
Guan JG, Miao YQ, Zhang QJ (2004) Impedimetric biosensors. J Biosci Bioeng 97:219–226
Grieshaber D, Mackenzie R, Vörös J, Reimhult E (2008) Electrochemical biosensors -sensor principles and architectures. Sensors 8:1400–1458
González-Rumayor V, García-Iglesias E, Ruíz-Gálan O, Gago-Cabezas L (2005) Aplicaciones de biosensores en la industria agroalimentaria. CEIM Dir. Gen. Universidades e Investig. Colección Vigil, Tecnológica, Madrid
Weetall HH (1996) Biosensor technology What? Where? When? and Why? Biosens Bioelectron 11:1–4
Wilson GS, Gifford R (2005) Biosensors for real-time in vivo measurements. Biosens Bioelectron 20:2388–2403
Mulchandani A (1998) Principles of enzyme biosensors. Enzyme Microb Biosens 6:3–14
Hall RH (2002) Biosensor technologies for detecting microbiological foodborne hazards. Microbes Infect 4:425–432
Kissinger PT (2005) Biosensors – a perspective. Biosens Bioelectron 20:2512–2516
Yakovleva M, Bhand S, Danielsson B (2013) The enzyme thermistor-A realistic biosensor concept. A critical review. Anal Chim Acta 766:1–12
Vijayalakshmi A, Tarunashree Y, Baruwati B et al (2008) Enzyme field effect transistor (ENFET) for estimation of triglycerides using magnetic nanoparticles. Biosens Bioelectron 23:1708–1714
Dzyadevych SV, Soldatkin AP, Korpan YI et al (2003) Biosensors based on enzyme field-effect transistors for determination of some substrates and inhibitors. Anal Bioanal Chem 377:496–506
Dzyadevych SV, Soldatkin AP, El’skaya AV et al (2006) Enzyme biosensors based on ion-selective field-effect transistors. Anal Chim Acta 568:248–258
Choi MMF (2004) Progress in enzyme-based biosensors using optical transducers. Microchim Acta 148:107–132
Das P, Das M, Chinnadayyala SR et al (2016) Recent advances on developing 3rd generation enzyme electrode for biosensor applications. Biosens Bioelectron 79:386–397
Zhao Z, Jiang H (2010) Enzyme-based electrochemical biosensors. In: Biosensors. INTECH, pp 1–22
Dsouza SF (1999) Immobilized enzymes in bioprocess. Curr Sci India 77:69–79
Arya SK, Datta M, Malhotra BD (2008) Recent advances in cholesterol biosensor. Biosens Bioelectron 23:1083–1100
Silva Nunes G, Marty J-L (2006) Immobilization of enzymes on electrodes. In: Guisan JM (ed) Immobilization of enzymes and cells. Humana Press, Totowa, NJ, pp 239–250
Zhang S, Wright G, Yang Y (2000) Materials and techniques for electrochemical biosensor design and construction. Biosens Bioelectron 15:273–282
Sassolas A, Blum LJ, Leca-Bouvier BD (2012) Immobilization strategies to develop enzymatic biosensors. Biotechnol Adv 30:489–511
Jianrong C, Yuqing M, Nongyue H et al (2004) Nanotechnology and biosensors. Biotechnol Adv 22:505–518
Li H, Liu S, Dai Z et al (2009) Applications of nanomaterials in electrochemical enzyme biosensors. Sensors 9:8547–8561
Pumera M, Sánchez S, Ichinose I, Tang J (2007) Electrochemical nanobiosensors. Sensors Actuators B Chem 123:1195–1205
Trojanowicz M (2006) Analytical applications of carbon nanotubes: a review. TrAC - Trends Anal Chem 25:480–489
Sarma AK, Vatsyayan P, Goswami P, Minteer SD (2009) Recent advances in material science for developing enzyme electrodes. Biosens Bioelectron 24:2313–2322
Kuila T, Bose S, Khanra P et al (2011) Recent advances in graphene-based biosensors. Biosens Bioelectron 26:4637–4648
Georgia-Paraskevi N, Siontorou C, Nikolelis D et al (2017) Biosensors based on lipid modified graphene microelectrodes. C 3:9
Arduini F, Cinti S, Scognamiglio V, Moscone D (2016) Nanomaterials in electrochemical biosensors for pesticide detection: advances and challenges in food analysis. Microchim Acta 183:2063–2083
Saxena U, Das AB (2016) Nanomaterials towards fabrication of cholesterol biosensors: key roles and design approaches. Biosens Bioelectron 75:196–205
Casas-Godoy L, Duquesne S, Bordes F et al (2012) Lipases: an overview. In: Sandoval G (ed) Lipases phospholipases methods protocols. Humana Press, Totowa, NJ, pp 3–30
Petry S, Baringhaus K, Schoenafinger K et al (2004) High-throughput screening of hormone-sensitive lipase and subsequent computer-assisted compound optimization. In: Lipases and phospholipases in drug development: from biochemistry to molecular pharmacology. Wiley-VCH, Weinheim, pp 121–137
Deeth H, Touch V (2000) Methods for detecting lipase activity in milk and milk products. Aust J Dairy Technol 55:153–168
Wahler D, Jean-Louis R (2001) Novel methods for biocatalyst screening. Curr Opin Chem Biol 5:152–158
Starodub NF (2006) Biosensors for the evaluation of lipase activity. J Mol Catal B Enzym 40:155–160
Ge K, Liu D, Chen K, Nie L, Yao S (1995) Assay of pancreatic lipase with the surface acoustic wave sensor system. Anal Biochem 226:207–211
Wei W, Wang R, Nie L, Yao S (1997) Rapid determination of dimethoate with a surface acoustic wave impedance sensor system. Anal Lett 30:2641–2653
Ben Rejeb I, Arduini F, Amine A et al (2007) Amperometric biosensor based on Prussian Blue-modified screen-printed electrode for lipase activity and triacylglycerol determination. Anal Chim Acta 594:1–8
Okazaki M, Komoriya N, Tomoike H et al (1998) Quantitative detection method of triglycerides in serum lipoproteins and serum-free glycerol by high-performance liquid chromatography. J Chromatogr B Biomed Appl 709:179–187
Vakhlu J, Kour A (2006) Yeast lipases: enzyme purification, biochemical properties and gene cloning. Electron J Biotechnol 9:69–85
Wladyslaw T, Pijanowska D (2007) Microsystems in biochemical diagnosis. Biocybern Biomed Eng 27:33–43
Pijanowska DG, Baraniecka A, Wiater R et al (2001) The pH-detection of triglycerides. Sensors Actuators B Chem 78:263–266
Reddy RRK, Chadha A, Bhattacharya E (2001) Porous silicon based potentiometric triglyceride biosensor. Biosens Bioelectron 16:313–317
Laurinavicius V, Kurtinaitiene B, Gureviciene V et al (1996) Amperometric glyceride biosensor. Anal Chim Acta 330:159–166
Wu LC, Cheng CM (2005) Flow-injection enzymatic analysis for glycerol and triacylglycerol. Anal Biochem 346:234–240
Narang J, Minakshi BM, Pundir CS (2010) Determination of serum triglyceride by enzyme electrode using covalently immobilized enzyme on egg shell membrane. Int J Biol Macromol 47:691–695
Dhand C, Solanki PR, Datta M, Malhotra BD (2010) Polyaniline/single-walled carbon nanotubes composite based triglyceride biosensor. Electroanalysis 22:2683–2693
Solanki PR, Kaushik A, Agrawal VV, Malhotra BD (2011) Nanostructured metal oxide-based biosensors. NPG Asia Mater 3:17–24
Ganjali MR, Faridbod F, Nasli-Esfahani E et al (2010) FFT continuous cyclic voltammetry triglyceride dual enzyme biosensor based on MWCNTs-CeO2 nanoparticles. Int J Electrochem Sci 5:1422–1433
Hsu SY, Bartling B, Wang C et al (2010) Enzymatic determination of diglyceride using an iridium nano-particle based single use, disposable biosensor. Sensors 10:5758–5773
Fernandez RE, Hareesh V, Bhattacharya E, Chadha A (2009) Comparison of a potentiometric and a micromechanical triglyceride biosensor. Biosens Bioelectron 24:1276–1280
Charpentier L, El Murr N (1995) Amperometric determination of cholesterol in serum with use of a renewable surface peroxidase electrode. Anal Chim Acta 318:89–93
Pliego J, Mateos JC, Rodriguez J et al (2015) Monitoring lipase/esterase activity by stopped flow in a sequential injection analysis system using p-nitrophenyl butyrate. Sensors 15:2798–2811
Huang XR, Li YZ, Yang GL, Liu LL (2001) A novel method for fabrication of a glass-electrode-based lipase sensor. Chinese Chem Lett 12:453–456
Minakshi, Pundir CS (2008) Construction of an amperometric enzymic sensor for triglyceride determination. Sensors Actuators B Chem 133:251–255
Dhand C, Solanki PR, Sood KN et al (2009) Polyaniline nanotubes for impedimetric triglyceride detection. Electrochem Commun 11:1482–1486
Solanki PR, Dhand C, Kaushik A et al (2009) Nanostructured cerium oxide film for triglyceride sensor. Sensors Actuators B Chem 141:551–556
Pundir CS, Sandeep Singh B, Narang J (2010) Construction of an amperometric triglyceride biosensor using PVA membrane bound enzymes. Clin Biochem 43:467–472
Phongphut A, Sriprachuabwong C, Wisitsoraat A et al (2013) A disposable amperometric biosensor based on inkjet-printed au/PEDOT-PSS nanocomposite for triglyceride determination. Sensors Actuators B Chem 178:501–507
Jeong CY, Han YD, Yoon JH, Yoon HC (2014) Bioelectrocatalytic sensor for triglycerides in human skin sebum based on enzymatic cascade reaction of lipase, glycerol kinase and glycerophosphate oxidase. J Biotechnol 175:7–14
Yücel A, Özcan HM, Sağıroğlu A (2016) A new multienzyme-type biosensor for triglyceride determination. Prep Biochem Biotechnol 46:78–84
Solanki S, Pandey CM, Soni A et al (2016) An amperometric bienzymatic biosensor for the triglyceride tributyrin using an indium tin oxide electrode coated with electrophoretically deposited chitosan-wrapped nanozirconia. Microchim Acta 183:167–176
Pundir CS, Aggarwal V (2017) Amperometric triglyceride bionanosensor based on nanoparticles of lipase, glycerol kinase, glycerol-3-phosphate oxidase. Anal Biochem 517:56–63
Narwal V, Pundir CS (2017) An improved amperometric triglyceride biosensor based on co-immobilization of nanoparticles of lipase, glycerol kinase and glycerol 3-phosphate oxidase onto pencil graphite electrode. Enzym Microb Technol 100:11–16
Bodade A, Taiwade M, Chaudhari G (2017) Bioelectrode based chitosan-nano copper oxide for application to lipase biosensor. J Appl Pharm Res 5:30–39
Zhu M, Yang Z, Cheng Y et al (2017) Development of triglyceride biosensor based on the polydopamine-gold nanocomposite. Int J Electrochem Sci 12:6863–6873
Mondal K, Ali MA, Singh C et al (2017) Highly sensitive porous carbon and metal/carbon conducting nanofiber based enzymatic biosensors for triglyceride detection. Sensors Actuators B Chem 246:202–214
Xu T, Chi B, Chu M et al (2018) Hemocompatible ɛ-polylysine-heparin microparticles: a platform for detecting triglycerides in whole blood. Biosens Bioelectron 99:571–577
Chen Y, Xiao L, Liu Y et al (2014) A lipase-based electrochemical biosensor for target DNA. Microchim Acta 181:615–621
Reddy KG, Madhavi G, Swamy BEK et al (2013) Electrochemical investigations of lipase enzyme activity inhibition by methyl parathion pesticide: voltammetric studies. J Mol Liq 180:26–30
Situmorang M, Alexander PW, Hibbert DB (1999) Flow injection potentiometry for enzymatic assay of cholesterol with a tungsten electrode sensor. Talanta 49:639–649
Foster R, Cassidy J, O’Donoghue E (2000) Electrochemical diagnostic strip device for total cholesterol and its subfractions. Electroanalysis 12:716–721
Malik V, Pundir C (2002) Determination of total cholesterol in serum by cholesterol esterase and cholesterol oxidase immobilized and co-immobilized on to arylamine glass. Pakistan J Biol Sci 35:191–197
Martin SP, Lamb DJ, Lynch JM, Reddy SM (2003) Enzyme-based determination of cholesterol using the quartz crystal acoustic wave sensor. Anal Chim Acta 487:91–100
Suman, Pundir CS (2003) Co-immobilization of cholesterol esterase, cholesterol oxidase and peroxidase onto alkylamine glass beads for measurement of total cholesterol in serum. Curr Appl Phys 3:129–133
Basu AK, Chattopadhyay P, Roychoudhuri U, Chakraborty R (2007) Development of cholesterol biosensor based on immobilized cholesterol esterase and cholesterol oxidase on oxygen electrode for the determination of total cholesterol in food samples. Bioelectrochemistry 70:375–379
Hooda V, Gahlaut A, Kumar H, Pundir CS (2009) Biosensor based on enzyme coupled PVC reaction cell for electrochemical measurement of serum total cholesterol. Sensors Actuators B Chem 136:235–241
Wei-Chung S, Mei-Chun Y, Meng-Shan L (2009) Development of disposable lipid biosensor for the determination of total cholesterol. Biosens Bioelectron 24:1679–1684
Yoneyama Y, Yonemori Y, Murata M et al (2009) Wireless biosensor system for real-time cholesterol monitoring in fish “Nile tilapia”. Talanta 80:909–915
Safavi A, Farjami F (2011) Electrodeposition of gold-platinum alloy nanoparticles on ionic liquid-chitosan composite film and its application in fabricating an amperometric cholesterol biosensor. Biosens Bioelectron 26:2547–2552
Fang C, He J, Chen Z (2011) A disposable amperometric biosensor for determining total cholesterol in whole blood. Sensors Actuators B Chem 155:545–550
Vidal JC, Garcia-Ruiz E, Espuelas J et al (2003) Comparison of biosensors based on entrapment of cholesterol oxidase and cholesterol esterase in electropolymerized films of polypyrrole and diaminonaphthalene derivatives for amperometric determination of cholesterol. Anal Bioanal Chem 377:273–280
Singh S, Chaubey A, Malhotra BD (2004) Amperometric cholesterol biosensor based on immobilized cholesterol esterase and cholesterol oxidase on conducting polypyrrole films. Anal Chim Acta 502:229–234
Salinas E, Rivero V, Torriero AAJ et al (2006) Multienzymatic-rotating biosensor for total cholesterol determination in a FIA system. Talanta 70:244–250
Singh S, Solanki PR, Pandey MK, Malhotra BD (2006) Cholesterol biosensor based on cholesterol esterase, cholesterol oxidase and peroxidase immobilized onto conducting polyaniline films. Sensors Actuators B Chem 115:534–541
Singh S, Solanski PR, Pandey M, Malhotra B (2006) Covalent immobilization of cholesterol esterase and cholesterol oxidase on polyaniline films for application to cholesterol biosensor. Anal Chim Acta 568:126–132
Aravamudhan S, Ramgir NS, Bhansali S (2007) Electrochemical biosensor for targeted detection in blood using aligned Au nanowires. Sensors Actuators B Chem 127:29–35
Singh S, Singhal R, Malhotra BD (2007) Immobilization of cholesterol esterase and cholesterol oxidase onto sol-gel films for application to cholesterol biosensor. Anal Chim Acta 582:335–343
Dey RS, Raj CR (2010) Development of an amperometric cholesterol biosensor based on graphene-Pt nanoparticle hybrid material. J Phys Chem C 114:21427–21433
Ahmadalinezhad A, Chen A (2011) High-performance electrochemical biosensor for the detection of total cholesterol. Biosens Bioelectron 26:4508–4513
Manjunatha R, Shivappa Suresh G, Savio Melo J et al (2012) An amperometric bienzymatic cholesterol biosensor based on functionalized graphene modified electrode and its electrocatalytic activity towards total cholesterol determination. Talanta 99:302–309
Singh K, Chauhan R, Solanki PR, Basu T (2013) Development of impedimetric biosensor for total cholesterol estimation based on polypyrrole and platinum nanoparticle multi layer nanocomposite. Int J Org Chem 3:262–274
Feng B, Liu Y (2015) A disposable cholesterol enzyme biosensor based on ferrocene-capped gold nanoparticle modified screen-printed carbon electrode. Int J Electrochem Sci 10:4770–4778
Dhyani H, Ali MA, Pal SP et al (2015) Mediator-free biosensor using chitosan capped CdS quantum dots for detection of total cholesterol. RSC Adv 5:45928–45934
Aggarwal V, Malik J, Prashant A et al (2016) Amperometric determination of serum total cholesterol with nanoparticles of cholesterol esterase and cholesterol oxidase. Anal Biochem 500:6–11
Lata K, Dhull V, Hooda V (2016) Fabrication and optimization of ChE/ChO/HRP-AuNPs/c-MWCNTs based silver electrode for determining total cholesterol in serum. Biochem Res Int 2016:1–11
Huang Y, Cui L, Xue Y et al (2017) Ultrasensitive cholesterol biosensor based on enzymatic silver deposition on gold nanoparticles modified screen-printed carbon electrode. Mater Sci Eng C 77:1–8
Rahman MM, Xiao-Bo L, Kim J et al (2014) A cholesterol biosensor based on a bi-enzyme immobilized on conducting poly(thionine) film. Sensors Actuators B Chem 202:536–542
Munir S, Khan M, Soo-Young P (2015) Bienzyme liquid-crystal-based cholesterol biosensor. Sensors Actuators B Chem 220:508–515
Xu S, Wang Y, Zhou D et al (2016) A novel chemiluminescence sensor for sensitive detection of cholesterol based on the peroxidase-like activity of copper nanoclusters. Sci Rep 6:1–7
Xu L, Hou Y, Zhang M et al (2016) A novel electrochemical biosensor for detection of cholesterol. Russ J Electrochem 52:239–244
Tang S, Zhao Q, Tu Y (2016) A sensitive electrochemiluminescent cholesterol biosensor based on Au/hollowed-TiO2 nano-composite pre-functionalized electrode. Sensors Actuators B Chem 237:416–422
Dervisevic M, Çevik E, Şenel M et al (2016) Amperometric cholesterol biosensor based on reconstituted cholesterol oxidase on boronic acid functional conducting polymers. J Electroanal Chem 776:18–24
Umar A, Ahmad R, Kumar R et al (2016) Bi2O2CO3 nanoplates: fabrication and characterization of highly sensitive and selective cholesterol biosensor. J Alloys Compd 683:433–438
Lin X, Ni Y, Kokot S (2016) Electrochemical cholesterol sensor based on cholesterol oxidase and MoS2-AuNPs modified glassy carbon electrode. Sensors Actuators B Chem 233:100–106
Xu Z, Cheng X, Tan J, Gan X (2016) Fabrication of multiwalled carbon nanotube – polyaniline/platinum nanocomposite films toward improved performance for a cholesterol amperometric biosensor. Biotechnol Appl Biochem 63:757–764
Huang J, Liu Y, Zhang P et al (2017) A temperature-triggered fiber optic biosensor based on hydrogel-magnetic immobilized enzyme complex for sequential determination of cholesterol and glucose. Biochem Eng J 125:123–128
Martín M, Salazar P, Álvarez R et al (2017) Cholesterol biosensing with a polydopamine-modified nanostructured platinum electrode prepared by oblique angle physical vacuum deposition. Sensors Actuators B Chem 240:37–45
Hassanzadeh J, Khataee A (2018) Ultrasensitive chemiluminescent biosensor for the detection of cholesterol based on synergetic peroxidase-like activity of MoS2 and graphene quantum dots. Talanta 178:992–1000
Hok-Hay S, van der Meer IM, Hofman A et al (2005) Lipoprotein-associated phospholipase A2 activity is associated with risk of coronary heart disease and ischemic stroke: the Rotterdam study. Circulation 111:570–575
Vrbova E, Kroupovs I, Novotna Z (1993) Determination of phospholipase D activity with a choline biosensor. Anal Chim Acta 280:43–48
Marazuela MD, Moreno-Bondi MC (1998) Determination of choline-containing phospholipids in serum with a fiber-optic biosensor. Anal Chim Acta 374:19–29
Razola SS, Pochet S, Grosfils K, Kauffmann JM (2002) Amperometric determination of choline released from rat submandibular gland acinar cells using a choline oxidase biosensor. Biosens Bioelectron 18:185–191
Yang M, Yang Y, Yang Y et al (2004) Bienzymatic amperometric biosensor for choline based on mediator thionine in situ electropolymerized within a carbon paste electrode. Anal Biochem 334:127–134
Pati S, Palmisano F, Quinto M, Zambonin PG (2005) Quantitation of major choline fractions in milk and dietary supplements using a phospholipase D bioreactor coupled to a choline amperometric biosensor. J Agric Food Chem 53:6974–6979
End P, Gout I, Fry MJ et al (1993) A biosensor approach to probe the structure and function of the p85a subunit of the phosphatidylinositol 3-kinase complex. J Biol Chem 268:10066–10075
Mirsky VM, Mass M, Krause C, Wolfbeis OS (1998) Capacitive approach to determine phospholipase A(2) activity toward artificial and natural substrates. Anal Chem 70:3674–3678
Uesugi Y, Arima J, Iwabuchi M, Hatanaka T (2007) Sensor of phospholipids in Streptomyces phospholipase D. FEBS J 274:2672–2681
Wei-Yin L, Chung-Chiun L, Wang C (2008) Detection of lipoprotein-associated phospholipase A2 using a nano-iridium particle catalyst-based biosensor. Sensors Actuators B Chem 134:993–999
Hartono D, Lai SL, Yang KL, Yung LYL (2009) A liquid crystal-based sensor for real-time and label-free identification of phospholipase-like toxins and their inhibitors. Biosens Bioelectron 24:2289–2293
Aili D, Mager M, Roche D, Stevens MM (2011) Hybrid nanoparticle-liposome detection of phospholipase activity. Nano Lett 11:1401–1405
Wichmann O, Gelb MH, Schultz C (2007) Probing phospholipase A2 with fluorescent phospholipid substrates. Chem Bio Chem 8:1555–1569
Nishioka T, Frohman MA, Matsuda M, Kiyokawa E (2010) Heterogeneity of phosphatidic acid levels and distribution at the plasma membrane in living cells as visualized by a Forster Resonance Energy Transfer (FRET) biosensor. J Biol Chem 285:35979–35987
Mirsky VM, Krause C, Heckmann KD (1996) Capacitive sensor for lipolytic enzymes. Thin Solid Films 284–285:939–941
Rauch P, Ferri EN, Girotti S et al (1997) A chemiluminescent flow sensing device for determination of choline and phospholipase D activity in biological samples. Anal Biochem 245:133–140
Panfili G, Manzi P, Compagnone D et al (2000) Rapid assay of choline in foods using microwave hydrolysis and a choline biosensor. J Agric Food Chem 48:3403–3407
Pati S, Quinto M, Palmisano F, Zambonin PG (2004) Determination of choline in milk, milk powder, and soy lecithin hydrolysates by flow injection analysis and amperometric detection with a choline oxidase based biosensor. J Agric Food Chem 52:4638–4642
Song Z, Huang JD, Wu BY et al (2006) Amperometric aqueous sol-gel biosensor for low-potential stable choline detection at multi-wall carbon nanotube modified platinum electrode. Sensors Actuators B Chem 115:626–633
Shi H, Yang Y, Huang J et al (2006) Amperometric choline biosensors prepared by layer-by-layer deposition of choline oxidase on the Prussian blue-modified platinum electrode. Talanta 70:852–858
Liu SJ, Wen Q, Tang LJ, Jiang JH (2012) Phospholipid-graphene nanoassembly as a fluorescence biosensor for sensitive detection of phospholipase D activity. Anal Chem 84:5944–5950
Pal S, Sharma MK, Danielsson B et al (2014) A miniaturized nanobiosensor for choline analysis. Biosens Bioelectron 54:558–564
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Sandoval, G., Herrera-López, E.J. (2018). Lipase, Phospholipase, and Esterase Biosensors (Review). In: Sandoval, G. (eds) Lipases and Phospholipases. Methods in Molecular Biology, vol 1835. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8672-9_22
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DOI: https://doi.org/10.1007/978-1-4939-8672-9_22
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